Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 4421523..4422498 Replicon chromosome
Accession NZ_CP053980
Organism Bacillus thuringiensis strain FDAARGOS_795

Toxin (Protein)


Gene name spoIISA Uniprot ID C3GJ28
Locus tag FOC89_RS26155 Protein ID WP_003297560.1
Coordinates 4421523..4422260 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC89_RS26160 Protein ID WP_000588712.1
Coordinates 4422373..4422498 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC89_RS26130 4417055..4417462 + 408 WP_000072501.1 VOC family protein -
FOC89_RS26135 4417723..4418033 + 311 Protein_4450 hypothetical protein -
FOC89_RS26140 4418155..4419840 - 1686 WP_003297558.1 alpha-keto acid decarboxylase family protein -
FOC89_RS26145 4419947..4420429 + 483 WP_000191912.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC89_RS26150 4420597..4421334 + 738 WP_000594156.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC89_RS26155 4421523..4422260 + 738 WP_003297560.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC89_RS26160 4422373..4422498 + 126 WP_000588712.1 hypothetical protein Antitoxin
FOC89_RS26165 4422786..4423067 - 282 WP_001041555.1 hypothetical protein -
FOC89_RS26170 4423502..4423678 + 177 WP_000808045.1 hypothetical protein -
FOC89_RS26175 4423822..4425291 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
FOC89_RS26180 4425855..4426325 - 471 WP_000670597.1 DUF5065 family protein -
FOC89_RS26185 4426502..4427122 + 621 WP_002036390.1 SGNH/GDSL hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.07 Da        Isoelectric Point: 8.2672

>T158368 WP_003297560.1 NZ_CP053980:4421523-4422260 [Bacillus thuringiensis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T158368 NZ_CP069627:c4881536-4881429 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT158368 WP_000588712.1 NZ_CP053980:4422373-4422498 [Bacillus thuringiensis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT158368 NZ_CP069627:4881592-4881653 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9EK80

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References