158364

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3227158..3228133 Replicon chromosome
Accession NZ_CP053965
Organism Bacillus cereus strain FDAARGOS_802

Toxin (Protein)


Gene name spoIISA Uniprot ID C2NHW3
Locus tag FOC96_RS20105 Protein ID WP_002002796.1
Coordinates 3227396..3228133 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC96_RS20100 Protein ID WP_000588712.1
Coordinates 3227158..3227283 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC96_RS20075 3222903..3223373 + 471 WP_000771846.1 DUF5065 family protein -
FOC96_RS20080 3223959..3225428 - 1470 WP_000287551.1 beta-Ala-His dipeptidase -
FOC96_RS20085 3225572..3225748 - 177 WP_000852618.1 hypothetical protein -
FOC96_RS20090 3226087..3226323 + 237 WP_001021690.1 hypothetical protein -
FOC96_RS20095 3226603..3226884 + 282 WP_001041559.1 hypothetical protein -
FOC96_RS20100 3227158..3227283 - 126 WP_000588712.1 hypothetical protein Antitoxin
FOC96_RS20105 3227396..3228133 - 738 WP_002002796.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC96_RS20110 3228322..3229059 - 738 WP_000594157.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC96_RS20115 3229227..3229709 - 483 WP_000191909.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC96_RS20120 3229816..3230620 + 805 Protein_3256 alpha-keto acid decarboxylase family protein -
FOC96_RS20125 3230928..3231812 - 885 WP_000795513.1 hypothetical protein -
FOC96_RS20130 3231940..3232641 - 702 WP_001294994.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28283.98 Da        Isoelectric Point: 8.2998

>T158364 WP_002002796.1 NZ_CP053965:c3228133-3227396 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNAAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTTFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T158364 NZ_CP069627:3547829-3548143 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT158364 WP_000588712.1 NZ_CP053965:c3227283-3227158 [Bacillus cereus]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT158364 NZ_CP069627:3547593-3547826 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D3YFM0

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References