Detailed information of TA system TA158360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1969236..1969710
• Replicon: chromosome
• Accession: NZ_CP053957
• Organism: Staphylococcus capitis strain FDAARGOS_753

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A4U9TFJ6
• Locus tag: FOC61_RS09580
• Protein ID: WP_002452783.1
• Coordinates: 1969525..1969710 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: FOC61_RS09575
• Protein ID: WP_002452784.1
• Coordinates: 1969236..1969496 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC61_RS09540	1964482..1965204	-	723	WP_002452791.1	type I 3-dehydroquinate dehydratase	-
FOC61_RS09545	1965374..1965796	+	423	WP_002452790.1	organic hydroperoxide resistance protein	-
FOC61_RS09550	1966198..1966704	+	507	WP_002452789.1	GNAT family N-acetyltransferase	-
FOC61_RS09555	1966891..1967508	+	618	WP_002452788.1	LysE/ArgO family amino acid transporter	-
FOC61_RS09560	1967570..1968154	-	585	WP_002452787.1	phosphoglycerate mutase family protein	-
FOC61_RS09565	1968367..1968603	+	237	WP_002452786.1	hypothetical protein	-
FOC61_RS09570	1968595..1968798	-	204	WP_002452785.1	sterile alpha motif-like domain-containing protein	-
FOC61_RS09575	1969236..1969496	+	261	WP_002452784.1	hypothetical protein	Antitoxin
FOC61_RS09580	1969525..1969710	+	186	WP_002452783.1	hypothetical protein	Toxin
FOC61_RS09585	1969867..1970451	+	585	WP_002452782.1	hypothetical protein	-
FOC61_RS09590	1970510..1970743	-	234	WP_002433190.1	hypothetical protein	-
FOC61_RS09595	1970875..1971483	-	609	WP_002452781.1	GNAT family N-acetyltransferase	-
FOC61_RS09600	1971664..1972410	+	747	WP_002452780.1	poly-gamma-glutamate hydrolase family protein	-
FOC61_RS09605	1972531..1972815	+	285	WP_002452779.1	hypothetical protein	-
FOC61_RS09610	1972839..1973063	+	225	WP_002452778.1	hypothetical protein	-
FOC61_RS09615	1973372..1974106	-	735	WP_002452777.1	SGNH/GDSL hydrolase family protein	-
FOC61_RS09620	1974235..1974435	-	201	WP_002433447.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (4-57)

Antitoxin

• Endoribonuclease antitoxin GhoS (5-94)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6964.67 Da
• Isoelectric Point: 10.2299

>T158360 WP_002452783.1 NZ_CP053957:1969525-1969710 [Staphylococcus capitis]
VSLHFQILLWLAIIFIVAGAIILTIMLKTKKAERKESYLGFTVIFLIFGFAMLIYTLIFGL

Nucleotide

• Length: 186 bp

>T158360 NZ_CP069627:3172060-3172233 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9726.77 Da
• Isoelectric Point: 3.8758

>AT158360 WP_002452784.1 NZ_CP053957:1969236-1969496 [Staphylococcus capitis]
MKVFSINVINIILTILFVAFNVLITYNANVDNQLWLIPGLCICGVALFTSLIIAIIYTDLLSEILFFINIVLALYYIYPI
FTTSCN

Nucleotide

• Length: 261 bp

>AT158360 NZ_CP069627:3171736-3172032 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A4U9TFJ6