Detailed information of TA system TA158359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1038304..1039110
• Replicon: chromosome
• Accession: NZ_CP053957
• Organism: Staphylococcus capitis strain FDAARGOS_753

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FOC61_RS05165
• Protein ID: WP_002453558.1
• Coordinates: 1038304..1038768 (-)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FOC61_RS05170
• Protein ID: WP_002453557.1
• Coordinates: 1038781..1039110 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC61_RS05150	1034106..1035170	-	1065	WP_002453561.1	tyrosine-type recombinase/integrase	-
FOC61_RS05155	1035224..1036294	-	1071	WP_002453560.1	restriction endonuclease subunit S	-
FOC61_RS05160	1036278..1038149	-	1872	WP_039973891.1	N-6 DNA methylase	-
FOC61_RS05165	1038304..1038768	-	465	WP_002453558.1	ImmA/IrrE family metallo-endopeptidase	Toxin
FOC61_RS05170	1038781..1039110	-	330	WP_002453557.1	helix-turn-helix transcriptional regulator	Antitoxin
FOC61_RS05175	1039304..1039543	+	240	WP_002453556.1	helix-turn-helix domain-containing protein	-
FOC61_RS05180	1039555..1039788	+	234	WP_002453555.1	DUF2829 domain-containing protein	-
FOC61_RS05185	1039810..1039974	+	165	WP_002453554.1	hypothetical protein	-
FOC61_RS05190	1039978..1040190	+	213	WP_002453553.1	DUF771 domain-containing protein	-
FOC61_RS05195	1040203..1040379	+	177	WP_002453552.1	hypothetical protein	-
FOC61_RS05200	1040443..1040679	+	237	WP_039973868.1	hypothetical protein	-
FOC61_RS05205	1040672..1041157	+	486	WP_002453550.1	siphovirus Gp157 family protein	-
FOC61_RS05210	1041158..1041859	+	702	WP_002453549.1	AAA family ATPase	-
FOC61_RS05215	1041846..1043255	+	1410	WP_002453548.1	DEAD/DEAH box helicase	-
FOC61_RS05220	1043273..1043821	+	549	WP_002453547.1	DUF669 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1005989..1091676	85687

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (33-121)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 18268.81 Da
• Isoelectric Point: 5.0632

>T158359 WP_002453558.1 NZ_CP053957:c1038768-1038304 [Staphylococcus capitis]
VGKYEDMLIEHDYIEVIECDKLPNDLYGLWLGDMILINRNLPITSKLETLAEELAHNELTYGNIANQNNFNHRKFEGYAR
KLAYEKLVPLKDIVKAFLQDIHNLYELANFFEVTEGFVLQSIEHYKQKHGYSTRYGKYVIQFEPLRVFEYKDIE

Nucleotide

• Length: 465 bp

>T158359 NZ_CP069627:2864231-2864542 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12734.34 Da
• Isoelectric Point: 6.4826

>AT158359 WP_002453557.1 NZ_CP053957:c1039110-1038781 [Staphylococcus capitis]
MRNNDEIITIIKSAMKEQNMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Nucleotide

• Length: 330 bp

>AT158359 NZ_CP069627:2864543-2864833 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG