Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1008650..1009456 Replicon chromosome
Accession NZ_CP053957
Organism Staphylococcus capitis strain FDAARGOS_753

Toxin (Protein)


Gene name tsbT Uniprot ID A0A1J4EAU5
Locus tag FOC61_RS04990 Protein ID WP_002434789.1
Coordinates 1009277..1009456 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A1J4ECT8
Locus tag FOC61_RS04985 Protein ID WP_002453580.1
Coordinates 1008650..1009249 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC61_RS04965 1004539..1005996 + 1458 WP_002453584.1 ABC transporter substrate-binding protein/permease -
FOC61_RS04970 1005989..1006714 + 726 WP_002453583.1 amino acid ABC transporter ATP-binding protein -
FOC61_RS04975 1006833..1007996 + 1164 WP_100209048.1 tRNA epoxyqueuosine(34) reductase QueG -
FOC61_RS04980 1007999..1008469 + 471 WP_002453581.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
FOC61_RS04985 1008650..1009249 + 600 WP_002453580.1 glucosamine-6-phosphate isomerase Antitoxin
FOC61_RS04990 1009277..1009456 + 180 WP_002434789.1 hypothetical protein Toxin
FOC61_RS04995 1009621..1010019 + 399 WP_002453579.1 hypothetical protein -
FOC61_RS05000 1010172..1011557 + 1386 WP_002453578.1 class II fumarate hydratase -
FOC61_RS05005 1011655..1012485 - 831 WP_002453577.1 RluA family pseudouridine synthase -
FOC61_RS05010 1012661..1013773 + 1113 WP_002453576.1 GAF domain-containing sensor histidine kinase -
FOC61_RS05015 1013793..1014416 + 624 WP_002453575.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1005989..1091676 85687


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7005.38 Da        Isoelectric Point: 3.9242

>T158355 WP_002434789.1 NZ_CP053957:1009277-1009456 [Staphylococcus capitis]
MNKEHESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVRSDLNNE

Download         Length: 180 bp

>T158355 NZ_CP069627:c1661140-1660733 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22720.63 Da        Isoelectric Point: 4.7928

>AT158355 WP_002453580.1 NZ_CP053957:1008650-1009249 [Staphylococcus capitis]
MAMNFKVFENSERVAEYAADIIRKQFNNNPTTIAGFHLEKDHAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEQDAIDFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKREVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARYV

Download         Length: 600 bp

>AT158355 NZ_CP069627:c1661387-1661121 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4EAU5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4ECT8

References