Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 867230..867753 Replicon chromosome
Accession NZ_CP053957
Organism Staphylococcus capitis strain FDAARGOS_753

Toxin (Protein)


Gene name mazF Uniprot ID A0A1J4E8Y2
Locus tag FOC61_RS04190 Protein ID WP_002435799.1
Coordinates 867397..867753 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1J4E747
Locus tag FOC61_RS04185 Protein ID WP_002435513.1
Coordinates 867230..867400 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC61_RS04160 863057..863536 + 480 WP_002453690.1 PH domain-containing protein -
FOC61_RS04165 863529..865028 + 1500 WP_002453689.1 PH domain-containing protein -
FOC61_RS04170 865021..865521 + 501 WP_002453688.1 PH domain-containing protein -
FOC61_RS04175 865570..865926 + 357 WP_002453687.1 holo-ACP synthase -
FOC61_RS04180 865993..867141 + 1149 WP_002453686.1 alanine racemase -
FOC61_RS04185 867230..867400 + 171 WP_002435513.1 hypothetical protein Antitoxin
FOC61_RS04190 867397..867753 + 357 WP_002435799.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FOC61_RS04195 868132..869133 + 1002 WP_002453685.1 PP2C family protein-serine/threonine phosphatase -
FOC61_RS04200 869235..869561 + 327 WP_002435753.1 anti-sigma factor antagonist -
FOC61_RS04205 869563..870042 + 480 WP_002435518.1 anti-sigma B factor RsbW -
FOC61_RS04210 870017..870787 + 771 WP_002435824.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13327.44 Da        Isoelectric Point: 9.8770

>T158354 WP_002435799.1 NZ_CP053957:867397-867753 [Staphylococcus capitis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHQ

Download         Length: 357 bp

>T158354 NZ_CP069627:c1445824-1445513 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6263.87 Da        Isoelectric Point: 4.0121

>AT158354 WP_002435513.1 NZ_CP053957:867230-867400 [Staphylococcus capitis]
MLSFNQSRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT158354 NZ_CP069627:c1445516-1445097 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATACCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E8Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E747

References