158353

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 856194..856708 Replicon chromosome
Accession NZ_CP053957
Organism Staphylococcus capitis strain FDAARGOS_753

Toxin (Protein)


Gene name TsdT Uniprot ID A0A4U9TAG5
Locus tag FOC61_RS04130 Protein ID WP_002453694.1
Coordinates 856502..856708 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1J4E888
Locus tag FOC61_RS04125 Protein ID WP_002435858.1
Coordinates 856194..856487 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC61_RS04100 851354..852142 + 789 WP_002453699.1 hydroxyethylthiazole kinase -
FOC61_RS04105 852149..852787 + 639 WP_002453698.1 thiamine phosphate synthase -
FOC61_RS04110 852876..853748 + 873 WP_002453697.1 membrane protein insertase YidC -
FOC61_RS04115 853807..854469 - 663 WP_002453696.1 HD domain-containing protein -
FOC61_RS04120 854524..856008 - 1485 WP_002453695.1 cardiolipin synthase -
FOC61_RS04125 856194..856487 + 294 WP_002435858.1 copper-sensing transcriptional repressor CsoR Antitoxin
FOC61_RS04130 856502..856708 + 207 WP_002453694.1 hypothetical protein Toxin
FOC61_RS04135 856845..856982 + 138 WP_002435861.1 hypothetical protein -
FOC61_RS04140 857039..858250 - 1212 WP_002453693.1 rod shape-determining protein RodA -
FOC61_RS04145 858655..859725 + 1071 WP_002435813.1 D-alanine--D-alanine ligase -
FOC61_RS04150 859741..861096 + 1356 WP_016898669.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7805.85 Da        Isoelectric Point: 4.2087

>T158353 WP_002453694.1 NZ_CP053957:856502-856708 [Staphylococcus capitis]
MENGIVYVANIEAIEEENQLKTRLENMIGVEKVDIDSKVGEIKILFETPANLNSIEKEVYDSGFRVRY

Download         Length: 207 bp

>T158353 NZ_CP069627:c739690-739439 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11065.56 Da        Isoelectric Point: 6.4776

>AT158353 WP_002435858.1 NZ_CP053957:856194-856487 [Staphylococcus capitis]
VTENETAHHSEQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT158353 NZ_CP069627:c739442-739188 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9TAG5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E888

References