Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3909557..3910532 Replicon chromosome
Accession NZ_CP053955
Organism Bacillus tropicus strain FDAARGOS_782

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7U6C7L7
Locus tag FOC76_RS20045 Protein ID WP_002021399.1
Coordinates 3909795..3910532 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A150BES9
Locus tag FOC76_RS20040 Protein ID WP_000594607.1
Coordinates 3909557..3909682 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC76_RS20015 3904605..3904993 - 389 Protein_3854 serine hydrolase -
FOC76_RS20020 3905527..3906186 - 660 WP_000682537.1 CatB-related O-acetyltransferase -
FOC76_RS20025 3906641..3907111 + 471 Protein_3856 DUF5065 family protein -
FOC76_RS20030 3907692..3909161 - 1470 WP_000287527.1 beta-Ala-His dipeptidase -
FOC76_RS20035 3909305..3909481 - 177 WP_000808046.1 hypothetical protein -
FOC76_RS20040 3909557..3909682 - 126 WP_000594607.1 hypothetical protein Antitoxin
FOC76_RS20045 3909795..3910532 - 738 WP_002021399.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC76_RS20050 3910721..3911458 - 738 WP_000594142.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC76_RS20055 3911626..3912108 - 483 WP_000191901.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC76_RS20060 3912215..3913900 + 1686 WP_002021397.1 alpha-keto acid decarboxylase family protein -
FOC76_RS20065 3914022..3914804 - 783 WP_000381795.1 class I SAM-dependent methyltransferase -
FOC76_RS20070 3915090..3915497 - 408 WP_000072483.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28331.03 Da        Isoelectric Point: 8.2638

>T158351 WP_002021399.1 NZ_CP053955:c3910532-3909795 [Bacillus tropicus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T158351 NZ_CP069627:727100-727474 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4888.29 Da        Isoelectric Point: 3.9798

>AT158351 WP_000594607.1 NZ_CP053955:c3909682-3909557 [Bacillus tropicus]
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT158351 NZ_CP069627:726643-727011 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6C7L7

Antitoxin

Source ID Structure
AlphaFold DB A0A150BES9

References