Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1283237..1284215 Replicon chromosome
Accession NZ_CP053951
Organism Bacillus cereus strain FDAARGOS_799

Toxin (Protein)


Gene name spoIISA Uniprot ID W8Y388
Locus tag FOC93_RS09775 Protein ID WP_000624977.1
Coordinates 1283478..1284215 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FOC93_RS09770 Protein ID WP_000237820.1
Coordinates 1283237..1283365 (-) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC93_RS09740 1278723..1278974 + 252 WP_000827560.1 response regulator transcription factor -
FOC93_RS09745 1279216..1279818 - 603 WP_000517260.1 hypothetical protein -
FOC93_RS09750 1279844..1280653 - 810 WP_000678509.1 C39 family peptidase -
FOC93_RS09755 1280899..1282368 - 1470 WP_000287515.1 beta-Ala-His dipeptidase -
FOC93_RS09760 1282580..1282969 + 390 WP_000713867.1 YxeA family protein -
FOC93_RS09765 1282988..1283164 - 177 WP_000852632.1 stage II sporulation protein SB -
FOC93_RS09770 1283237..1283365 - 129 WP_000237820.1 hypothetical protein Antitoxin
FOC93_RS09775 1283478..1284215 - 738 WP_000624977.1 stage II sporulation protein SA Toxin
FOC93_RS09780 1284453..1285190 - 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC93_RS09785 1285357..1285839 - 483 WP_000191888.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC93_RS09790 1285947..1287632 + 1686 WP_144502466.1 alpha-keto acid decarboxylase family protein -
FOC93_RS09795 1287790..1288170 - 381 WP_000497670.1 methyltransferase -
FOC93_RS09800 1288192..1288599 - 408 WP_000063589.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28307.03 Da        Isoelectric Point: 8.2998

>T158346 WP_000624977.1 NZ_CP053951:c1284215-1283478 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T158346 NZ_CP069624:c4882468-4882361 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5010.41 Da        Isoelectric Point: 3.9798

>AT158346 WP_000237820.1 NZ_CP053951:c1283365-1283237 [Bacillus cereus]
VVKDYDNDFFKENNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT158346 NZ_CP069624:4882524-4882585 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8Y388

Antitoxin

Source ID Structure

References