Detailed information of TA system TA158342

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2508399..2509035
• Replicon: chromosome
• Accession: NZ_CP053947
• Organism: Acinetobacter sp. WY4

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: N9MVT8
• Locus tag: G4D73_RS11755
• Protein ID: WP_004281482.1
• Coordinates: 2508649..2509035 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9QGE4
• Locus tag: G4D73_RS11750
• Protein ID: WP_005263749.1
• Coordinates: 2508399..2508656 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G4D73_RS11730	2503883..2504890	+	1008	WP_004281489.1	DNA-directed RNA polymerase subunit alpha	-
G4D73_RS11735	2504909..2505274	+	366	WP_004281488.1	50S ribosomal protein L17	-
G4D73_RS11740	2505492..2506982	+	1491	WP_213686826.1	NAD(P)/FAD-dependent oxidoreductase	-
G4D73_RS11745	2507043..2508215	-	1173	WP_191111866.1	acyl-CoA dehydrogenase family protein	-
G4D73_RS11750	2508399..2508656	+	258	WP_005263749.1	succinate dehydrogenase assembly factor 2	Antitoxin
G4D73_RS11755	2508649..2509035	+	387	WP_004281482.1	hypothetical protein	Toxin
G4D73_RS11760	2509570..2510610	+	1041	WP_213686827.1	hypothetical protein	-
G4D73_RS11765	2510678..2511250	+	573	WP_004281478.1	rhombosortase	-
G4D73_RS11770	2511448..2513730	+	2283	WP_213686828.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15269.41 Da
• Isoelectric Point: 9.9707

>T158342 WP_004281482.1 NZ_CP053947:2508649-2509035 [Acinetobacter sp. WY4]
MDNRCFKLKRSLCALAFQLFIFALLMYLLYQLLPIALWAVCAVIGLVIYQLFYRKTPQIEQFEYLDGREWSLTTKARPTR
RVCISHVIDHQAYIVVYFQHAKARPLLIWCDQLPFKQWKSLKLLTKLI

Nucleotide

• Length: 387 bp

>T158342 NZ_CP069624:3547829-3548143 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10313.79 Da
• Isoelectric Point: 4.6051

>AT158342 WP_005263749.1 NZ_CP053947:2508399-2508656 [Acinetobacter sp. WY4]
MTDDISLEERKVIYRARRGLKELDVYFDPYVKNHYLSAEPFEKQMFAELVEQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Nucleotide

• Length: 258 bp

>AT158342 NZ_CP069624:3547593-3547826 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: N9MVT8

Antitoxin

• AlphaFold DB: N9QGE4