Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2635799..2636774 | Replicon | chromosome |
| Accession | NZ_CP053934 | ||
| Organism | Bacillus thuringiensis strain FDAARGOS_794 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | C3G356 |
| Locus tag | FOC88_RS14130 | Protein ID | WP_003294136.1 |
| Coordinates | 2636037..2636774 (-) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | R8HWP4 |
| Locus tag | FOC88_RS14125 | Protein ID | WP_000588712.1 |
| Coordinates | 2635799..2635924 (-) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOC88_RS14095 | 2631554..2632024 | + | 471 | WP_000670597.1 | DUF5065 family protein | - |
| FOC88_RS14100 | 2632588..2634057 | - | 1470 | WP_000287522.1 | beta-Ala-His dipeptidase | - |
| FOC88_RS14105 | 2634201..2634377 | - | 177 | WP_000808045.1 | hypothetical protein | - |
| FOC88_RS14110 | 2634716..2634952 | + | 237 | WP_001021688.1 | hypothetical protein | - |
| FOC88_RS14115 | 2635229..2635510 | + | 282 | WP_001041555.1 | hypothetical protein | - |
| FOC88_RS14120 | 2635547..2635723 | - | 177 | WP_042511279.1 | hypothetical protein | - |
| FOC88_RS14125 | 2635799..2635924 | - | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
| FOC88_RS14130 | 2636037..2636774 | - | 738 | WP_003294136.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| FOC88_RS14135 | 2636963..2637700 | - | 738 | WP_000594156.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| FOC88_RS14140 | 2637868..2638350 | - | 483 | WP_000191912.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| FOC88_RS14145 | 2638457..2640142 | + | 1686 | WP_052495366.1 | alpha-keto acid decarboxylase family protein | - |
| FOC88_RS14150 | 2640264..2640574 | - | 311 | Protein_2709 | hypothetical protein | - |
| FOC88_RS14155 | 2640835..2641242 | - | 408 | WP_000072501.1 | VOC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28359.05 Da Isoelectric Point: 8.2672
>T158335 WP_003294136.1 NZ_CP053934:c2636774-2636037 [Bacillus thuringiensis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVVDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVVDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T158335 NZ_CP069624:2022971-2023435 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT158335 WP_000588712.1 NZ_CP053934:c2635924-2635799 [Bacillus thuringiensis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT158335 NZ_CP069624:2022636-2022971 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6H9IF90 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366GQT1 |