Detailed information of TA system TA158334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 4461191..4462166
• Replicon: chromosome
• Accession: NZ_CP053931
• Organism: Bacillus cereus strain FDAARGOS_797

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: FOC91_RS24445
• Protein ID: WP_052494343.1
• Coordinates: 4461429..4462166 (-)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: C2VTW9
• Locus tag: FOC91_RS24440
• Protein ID: WP_000588936.1
• Coordinates: 4461191..4461316 (-)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC91_RS24410	4456547..4457167	-	621	WP_127813147.1	SGNH/GDSL hydrolase family protein	-
FOC91_RS24415	4457344..4457814	+	471	WP_000670597.1	DUF5065 family protein	-
FOC91_RS24420	4458396..4459865	-	1470	WP_042512696.1	beta-Ala-His dipeptidase	-
FOC91_RS24425	4460009..4460185	-	177	WP_042512697.1	hypothetical protein	-
FOC91_RS24430	4460620..4460901	+	282	WP_001041554.1	hypothetical protein	-
FOC91_RS24435	4460938..4461114	-	177	WP_042512698.1	hypothetical protein	-
FOC91_RS24440	4461191..4461316	-	126	WP_000588936.1	hypothetical protein	Antitoxin
FOC91_RS24445	4461429..4462166	-	738	WP_052494343.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
FOC91_RS24450	4462355..4463092	-	738	WP_042512700.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
FOC91_RS24455	4463260..4463742	-	483	WP_042512701.1	MarR family winged helix-turn-helix transcriptional regulator	-
FOC91_RS24460	4463849..4464631	+	783	Protein_4521	alpha-keto acid decarboxylase family protein	-
FOC91_RS24465	4464951..4465835	-	885	WP_042512702.1	hypothetical protein	-
FOC91_RS24470	4465958..4466659	-	702	WP_001294994.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4438093..4566123	128030

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28358.10 Da
• Isoelectric Point: 8.9957

>T158334 WP_052494343.1 NZ_CP053931:c4462166-4461429 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T158334 NZ_CP069624:1802210-1802587 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4888.29 Da
• Isoelectric Point: 3.9798

>AT158334 WP_000588936.1 NZ_CP053931:c4461316-4461191 [Bacillus cereus]
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK

Nucleotide

• Length: 126 bp

>AT158334 NZ_CP069624:1801753-1802121 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Antitoxin

• AlphaFold DB: C2VTW9