Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4891591..4892228 Replicon chromosome
Accession NZ_CP053929
Organism Pseudomonas sp. B14-6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HP062_RS22405 Protein ID WP_010464625.1
Coordinates 4891591..4891998 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HP062_RS22410 Protein ID WP_083375253.1
Coordinates 4891998..4892228 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP062_RS22385 4887361..4888107 - 747 WP_172792047.1 ABC transporter substrate-binding protein -
HP062_RS22390 4888121..4888894 - 774 WP_007897462.1 ABC transporter ATP-binding protein -
HP062_RS22395 4889448..4890839 + 1392 WP_077747581.1 GABA permease -
HP062_RS22400 4891185..4891511 + 327 WP_010464627.1 hypothetical protein -
HP062_RS22405 4891591..4891998 - 408 WP_010464625.1 tRNA(fMet)-specific endonuclease VapC Toxin
HP062_RS22410 4891998..4892228 - 231 WP_083375253.1 antitoxin Antitoxin
HP062_RS22415 4892404..4892856 - 453 WP_145309168.1 hypothetical protein -
HP062_RS22420 4892862..4893278 - 417 WP_010464618.1 hypothetical protein -
HP062_RS22425 4893316..4894290 - 975 WP_172792048.1 alpha/beta fold hydrolase -
HP062_RS22430 4894363..4895412 - 1050 WP_172792049.1 DUF1016 family protein -
HP062_RS22435 4895681..4896130 + 450 WP_010464612.1 hypothetical protein -
HP062_RS22440 4896168..4896629 - 462 WP_010464610.1 DUF4234 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15067.44 Da        Isoelectric Point: 6.0845

>T158332 WP_010464625.1 NZ_CP053929:c4891998-4891591 [Pseudomonas sp. B14-6]
MIKFMLDTNICIFTIKNKPQIVREAFNLHDGQLCISAITLMELIYGAEKSATPEKNLAVIEGFTARLEVFPFDNEAAAHT
GMIRSELAKAGTPIGPYDQMIAGHARSRGLIVVTNNLREFERVPGLRVEDWVHPD

Download         Length: 408 bp

>T158332 NZ_CP069624:c1445824-1445513 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8710.71 Da        Isoelectric Point: 4.4720

>AT158332 WP_083375253.1 NZ_CP053929:c4892228-4891998 [Pseudomonas sp. B14-6]
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVNVFAIGRARIITPADETWDSWFDGDNVSTDFMTDRQQPADQERESF

Download         Length: 231 bp

>AT158332 NZ_CP069624:c1445516-1445097 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATACCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References