Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1989173..1989777 Replicon chromosome
Accession NZ_CP053929
Organism Pseudomonas sp. B14-6

Toxin (Protein)


Gene name PumA Uniprot ID A0A855KA05
Locus tag HP062_RS09005 Protein ID WP_010455649.1
Coordinates 1989173..1989466 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A024EJX4
Locus tag HP062_RS09010 Protein ID WP_010455651.1
Coordinates 1989469..1989777 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP062_RS08990 1984822..1986039 + 1218 WP_010455642.1 GNAT family N-acetyltransferase -
HP062_RS08995 1986011..1986802 + 792 WP_172791288.1 ChbG/HpnK family deacetylase -
HP062_RS09000 1986918..1987610 + 693 WP_172791289.1 N-acetyltransferase -
HP062_RS09005 1989173..1989466 + 294 WP_010455649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HP062_RS09010 1989469..1989777 + 309 WP_010455651.1 putative addiction module antidote protein Antitoxin
HP062_RS09015 1989791..1990603 - 813 WP_010455653.1 class I SAM-dependent methyltransferase -
HP062_RS09020 1990783..1991169 + 387 WP_010455655.1 hypothetical protein -
HP062_RS09025 1991173..1992600 - 1428 WP_145308181.1 sigma-54 dependent transcriptional regulator -
HP062_RS09030 1992569..1994062 - 1494 WP_172791290.1 HAMP domain-containing histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10646.39 Da        Isoelectric Point: 10.8628

>T158331 WP_010455649.1 NZ_CP053929:1989173-1989466 [Pseudomonas sp. B14-6]
MNYIVQQTMIFVAWHASVRDLRAKIAIARRIDRASAGNLGDIKPVGDGVSEMRVDVGAGYRVYFTLRNSVVIVLLAGGDK
SSQTADIRRAKKLAKEV

Download         Length: 294 bp

>T158331 NZ_CP069624:c739690-739439 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11043.61 Da        Isoelectric Point: 5.0482

>AT158331 WP_010455651.1 NZ_CP053929:1989469-1989777 [Pseudomonas sp. B14-6]
MSQTLTTFDMAALLDSDEAISEYLSQVLAEGDNEEFLRAIGYVVKARGMTQIAKDSGMGRESLYKAFAPGAKPRFDTVLK
VIHALGIDLCAQPGHSINHSVL

Download         Length: 309 bp

>AT158331 NZ_CP069624:c739442-739188 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855KA05

Antitoxin

Source ID Structure
AlphaFold DB A0A024EJX4

References