Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4627975..4628539 Replicon chromosome
Accession NZ_CP053928
Organism Nocardioides sp. WS12

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HRC28_RS22320 Protein ID WP_182380900.1
Coordinates 4627975..4628325 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HRC28_RS22325 Protein ID WP_182377562.1
Coordinates 4628309..4628539 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRC28_RS22300 4623271..4624215 - 945 WP_182377558.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
HRC28_RS22305 4624212..4625318 - 1107 WP_182377559.1 alpha/beta hydrolase -
HRC28_RS22310 4625315..4626499 - 1185 WP_182377560.1 alanine racemase -
HRC28_RS22315 4626516..4627967 - 1452 WP_182377561.1 NAD(P)H-hydrate dehydratase -
HRC28_RS22320 4627975..4628325 - 351 WP_182380900.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HRC28_RS22325 4628309..4628539 - 231 WP_182377562.1 ribbon-helix-helix protein, CopG family Antitoxin
HRC28_RS22330 4628587..4628940 - 354 WP_182377563.1 holo-ACP synthase -
HRC28_RS22335 4628947..4630791 - 1845 WP_182377564.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
HRC28_RS22340 4630856..4631854 + 999 WP_182377565.1 type I pantothenate kinase -
HRC28_RS22345 4631864..4632916 + 1053 WP_182377566.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12564.41 Da        Isoelectric Point: 10.6264

>T158329 WP_182380900.1 NZ_CP053928:c4628325-4627975 [Nocardioides sp. WS12]
IVRRGEVRLVDLEPARGSEASKRRPAVVVSNDRANAAADRLGRGVVTVVPVTSNVQRILPFQTLLPSEETGLRLDSKAQA
EQVRSVAVERIGAVLGRVPGHLMSDLDDALRLHLDL

Download         Length: 351 bp

>T158329 NZ_CP069624:727100-727474 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8209.97 Da        Isoelectric Point: 4.2676

>AT158329 WP_182377562.1 NZ_CP053928:c4628539-4628309 [Nocardioides sp. WS12]
MKLSVSLTDGDVALIDAYARESGLASRSAVVQLAVRHLRQASLEDDYDAAWREWESSGEEAAWAAATSDGLDRAAR

Download         Length: 231 bp

>AT158329 NZ_CP069624:726643-727011 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References