Detailed information of TA system TA158322

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3908317..3908973
• Replicon: chromosome
• Accession: NZ_CP053927
• Organism: Serratia marcescens strain 11/2010

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7DE55
• Locus tag: HP437_RS19605
• Protein ID: WP_047730091.1
• Coordinates: 3908317..3908706 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HP437_RS19610
• Protein ID: WP_180547580.1
• Coordinates: 3908710..3908973 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP437_RS19590	3904787..3906217	+	1431	WP_180547579.1	multidrug transporter subunit MdtD	-
HP437_RS19595	3906214..3907596	+	1383	WP_049202687.1	two-component system sensor histidine kinase BaeS	-
HP437_RS19600	3907596..3908312	+	717	WP_060441150.1	two-component system response regulator BaeR	-
HP437_RS19605	3908317..3908706	-	390	WP_047730091.1	type II toxin-antitoxin system VapC family toxin	Toxin
HP437_RS19610	3908710..3908973	-	264	WP_180547580.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HP437_RS19615	3909312..3909650	+	339	WP_038873760.1	YegP family protein	-
HP437_RS19620	3909952..3911304	+	1353	WP_060424878.1	tRNA 5-hydroxyuridine modification protein YegQ	-
HP437_RS19625	3911771..3912676	+	906	WP_180547581.1	lipid kinase YegS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14337.57 Da
• Isoelectric Point: 7.8794

>T158322 WP_047730091.1 NZ_CP053927:c3908706-3908317 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T158322 NZ_CP069621:c4039654-4039436 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10076.34 Da
• Isoelectric Point: 4.6702

>AT158322 WP_180547580.1 NZ_CP053927:c3908973-3908710 [Serratia marcescens]
MERIAKLFKNGRNQALRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT158322 NZ_CP069621:c4040054-4039680 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A5C7DE55