Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3151248..3151879 Replicon chromosome
Accession NZ_CP053927
Organism Serratia marcescens strain 11/2010

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HP437_RS16085 Protein ID WP_180547368.1
Coordinates 3151248..3151646 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HP437_RS16090 Protein ID WP_180547369.1
Coordinates 3151646..3151879 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP437_RS16060 3146822..3147193 + 372 WP_033647787.1 type II toxin-antitoxin system RelE/ParE family toxin -
HP437_RS16065 3147190..3147492 + 303 WP_038876832.1 DNA-binding transcriptional regulator -
HP437_RS16070 3147495..3147899 - 405 WP_180547366.1 flagellar protein FlhE -
HP437_RS16075 3147899..3149977 - 2079 WP_180547367.1 flagellar biosynthesis protein FlhA -
HP437_RS16080 3149970..3151121 - 1152 WP_047730459.1 flagellar type III secretion system protein FlhB -
HP437_RS16085 3151248..3151646 - 399 WP_180547368.1 type II toxin-antitoxin system VapC family toxin Toxin
HP437_RS16090 3151646..3151879 - 234 WP_180547369.1 antitoxin Antitoxin
HP437_RS16095 3152005..3152649 - 645 WP_180547370.1 protein phosphatase CheZ -
HP437_RS16100 3152660..3153049 - 390 WP_060420785.1 chemotaxis response regulator CheY -
HP437_RS16105 3153152..3154201 - 1050 WP_180547371.1 chemotaxis response regulator protein-glutamate methylesterase -
HP437_RS16110 3154201..3155073 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
HP437_RS16115 3155111..3156727 - 1617 WP_047730456.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14908.07 Da        Isoelectric Point: 8.4955

>T158319 WP_180547368.1 NZ_CP053927:c3151646-3151248 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTSIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T158319 NZ_CP069621:c3510894-3510742 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8913.91 Da        Isoelectric Point: 4.5702

>AT158319 WP_180547369.1 NZ_CP053927:c3151879-3151646 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDSVSKVTVRVVGKERILTPLENTWDSFFCAENEVSDDFLNERAGQYQREREDF

Download         Length: 234 bp

>AT158319 NZ_CP069621:3510943-3511000 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References