Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2011775..2012387 Replicon chromosome
Accession NZ_CP053927
Organism Serratia marcescens strain 11/2010

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag HP437_RS10520 Protein ID WP_012906750.1
Coordinates 2012208..2012387 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2F0PUM3
Locus tag HP437_RS10515 Protein ID WP_055312958.1
Coordinates 2011775..2012185 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP437_RS10485 2007304..2007666 + 363 WP_180548426.1 hypothetical protein -
HP437_RS10490 2007650..2008777 + 1128 WP_180548427.1 baseplate J/gp47 family protein -
HP437_RS10495 2008770..2009426 + 657 WP_180548428.1 DUF2612 domain-containing protein -
HP437_RS10500 2009413..2009730 + 318 Protein_1871 hypothetical protein -
HP437_RS10505 2010202..2010702 + 501 WP_180548675.1 phage tail protein -
HP437_RS10510 2010712..2011725 - 1014 WP_180548429.1 acyltransferase -
HP437_RS10515 2011775..2012185 - 411 WP_055312958.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HP437_RS10520 2012208..2012387 - 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
HP437_RS10525 2013490..2013897 + 408 WP_180548430.1 hypothetical protein -
HP437_RS10530 2014033..2014383 + 351 WP_004940949.1 DUF4377 domain-containing protein -
HP437_RS10535 2014434..2014736 - 303 WP_180548431.1 hypothetical protein -
HP437_RS10540 2015022..2016221 + 1200 WP_048322950.1 trans-2-enoyl-CoA reductase family protein -
HP437_RS10545 2016448..2016666 + 219 WP_064291234.1 hypothetical protein -
HP437_RS10550 2016838..2017143 + 306 WP_084826386.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1965127..2012387 47260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T158318 WP_012906750.1 NZ_CP053927:c2012387-2012208 [Serratia marcescens]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T158318 NZ_CP069621:3442279-3442566 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14889.72 Da        Isoelectric Point: 4.2855

>AT158318 WP_055312958.1 NZ_CP053927:c2012185-2011775 [Serratia marcescens]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIEAHIELLVEDGEAVPEGTNVETWLSDPDYAGVVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADRVISRENR

Download         Length: 411 bp

>AT158318 NZ_CP069621:3442553-3442855 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A2F0PUM3

References