Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1059764..1060386 Replicon chromosome
Accession NZ_CP053927
Organism Serratia marcescens strain 11/2010

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag HP437_RS05835 Protein ID WP_004940313.1
Coordinates 1059764..1059967 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag HP437_RS05840 Protein ID WP_004940312.1
Coordinates 1060018..1060386 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP437_RS05810 1055574..1056020 + 447 WP_180548184.1 type II secretion system protein M -
HP437_RS05815 1056056..1056871 + 816 WP_147839403.1 A24 family peptidase -
HP437_RS05820 1056868..1057230 - 363 WP_060423419.1 type II secretion system pilot lipoprotein GspS -
HP437_RS05825 1057483..1058910 + 1428 WP_060423422.1 N-acetylglucosamine-binding protein GbpA -
HP437_RS05830 1058963..1059481 + 519 WP_060423424.1 cytochrome b/b6 domain-containing protein -
HP437_RS05835 1059764..1059967 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
HP437_RS05840 1060018..1060386 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
HP437_RS05845 1060545..1060898 - 354 WP_060423427.1 hypothetical protein -
HP437_RS05850 1061171..1061311 + 141 WP_154292170.1 hypothetical protein -
HP437_RS05855 1061308..1062021 + 714 WP_060423430.1 ABC transporter ATP-binding protein -
HP437_RS05860 1062018..1062875 + 858 WP_060440564.1 metal ABC transporter permease -
HP437_RS05865 1062901..1063779 + 879 WP_089185570.1 metal ABC transporter substrate-binding protein -
HP437_RS05870 1063886..1064026 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
HP437_RS05875 1064039..1064293 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T158309 WP_004940313.1 NZ_CP053927:c1059967-1059764 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T158309 NZ_CP069621:c739690-739439 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT158309 WP_004940312.1 NZ_CP053927:c1060386-1060018 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT158309 NZ_CP069621:c739442-739188 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References