Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 54371..54906 Replicon chromosome
Accession NZ_CP053927
Organism Serratia marcescens strain 11/2010

Toxin (Protein)


Gene name relE Uniprot ID A0A5C7D971
Locus tag HP437_RS01030 Protein ID WP_033636570.1
Coordinates 54631..54906 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5C7DDR0
Locus tag HP437_RS01025 Protein ID WP_041037283.1
Coordinates 54371..54631 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP437_RS01005 49691..50341 + 651 WP_049202570.1 DcrB-related protein -
HP437_RS01010 50382..50987 + 606 WP_038875954.1 glutathione S-transferase -
HP437_RS01015 51056..52450 + 1395 WP_180547963.1 L-seryl-tRNA(Sec) selenium transferase -
HP437_RS01020 52447..54288 + 1842 WP_180547964.1 selenocysteine-specific translation elongation factor -
HP437_RS01025 54371..54631 + 261 WP_041037283.1 ribbon-helix-helix domain-containing protein Antitoxin
HP437_RS01030 54631..54906 + 276 WP_033636570.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HP437_RS01035 54918..55829 - 912 WP_180547965.1 LysR family transcriptional regulator -
HP437_RS01040 55951..56577 + 627 WP_087762495.1 LysE family translocator -
HP437_RS01045 56631..57878 - 1248 WP_038875940.1 MFS transporter -
HP437_RS01050 58096..59088 + 993 WP_084827003.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10578.32 Da        Isoelectric Point: 10.3377

>T158306 WP_033636570.1 NZ_CP053927:54631-54906 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T158306 NZ_CP069621:c398025-397923 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9653.95 Da        Isoelectric Point: 4.5084

>AT158306 WP_041037283.1 NZ_CP053927:54371-54631 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT158306 NZ_CP069621:397885-398153 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D971

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7DDR0

References