Detailed information of TA system TA158303

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4537308..4537977
• Replicon: chromosome
• Accession: NZ_CP053925
• Organism: Serratia marcescens strain 12/2010

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2V4FX75
• Locus tag: HP475_RS22155
• Protein ID: WP_033649453.1
• Coordinates: 4537308..4537730 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: HP475_RS22160
• Protein ID: WP_004931679.1
• Coordinates: 4537711..4537977 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP475_RS22135	4533197..4533715	+	519	WP_033635825.1	flavodoxin FldB	-
HP475_RS22140	4533753..4535117	-	1365	WP_049232284.1	cell envelope integrity protein CreD	-
HP475_RS22145	4535198..4536616	-	1419	WP_049232286.1	two-component system sensor histidine kinase CreC	-
HP475_RS22150	4536613..4537308	-	696	WP_049232287.1	two-component system response regulator CreB	-
HP475_RS22155	4537308..4537730	-	423	WP_033649453.1	protein YgfX	Toxin
HP475_RS22160	4537711..4537977	-	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
HP475_RS22165	4538298..4539290	+	993	WP_049232290.1	tRNA-modifying protein YgfZ	-
HP475_RS22170	4539329..4539826	-	498	WP_049232293.1	DUF2165 domain-containing protein	-
HP475_RS22175	4539977..4540651	-	675	WP_033654067.1	hemolysin III family protein	-
HP475_RS22180	4540835..4541443	+	609	WP_025304127.1	HD domain-containing protein	-
HP475_RS22185	4541475..4542401	-	927	WP_033635835.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16471.59 Da
• Isoelectric Point: 10.8114

>T158303 WP_033649453.1 NZ_CP053925:c4537730-4537308 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Nucleotide

• Length: 423 bp

>T158303 NZ_CP069620:c365775-365494 [Salinimicrobium sp. HN-2-9-2]
GTGATAAAATCATTTGCAGACAAGGAAGCTAACAAGATTTGGCATGGCACCCAGTTAAGAAAGCTTCCTGCTAATTTTCA
GAACGTGGCTCGAAGAAAATTAAGAATGATAAATAACGCTCAAAACATAAATGACTTGAGAATTCCTCCAGCTAACCACT
TAGAAAAACTGAGCGGAAACCTGGAAGGTTTTTATAGCATTAGAATTAACAAGCAATGGAGAATAATATTCAAATGGAAG
AATGACAGTGCATTTGAACTTCAAATCATTGATTACCATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT158303 WP_004931679.1 NZ_CP053925:c4537977-4537711 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT158303 NZ_CP069620:c365481-365182 [Salinimicrobium sp. HN-2-9-2]
ATGATAAAACTAGAAAACATACATCCCGGAGAAATTTTAAAGGAAGAATTTTTAGATCCGATGGAGATATCAGCTTATAG
ACTTTCCAAGGAAACCTTTATTCCCCAAACCCGAATTAGTGAGATCATTAAAAAGAAAAGAAGAATAACTGCCGATACGG
CACTTCGGCTCTCAAAATATTTTGGGACAACTGCAAAGTTTTGGTTAGGCTTACAGGATGATTACGATCTGGAAGAAGAA
AAAATCTTAAAGCAGGAAGAGTTGAGTAATATAAAGCCTTTGGAAAATAACCCGGCCTAA

Structures

Toxin

• AlphaFold DB: A0A2V4FX75