Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4028894..4029456 Replicon chromosome
Accession NZ_CP053925
Organism Serratia marcescens strain 12/2010

Toxin (Protein)


Gene name doc Uniprot ID A0A7D5Y033
Locus tag HP475_RS19725 Protein ID WP_033655000.1
Coordinates 4028894..4029250 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag HP475_RS19730 Protein ID WP_004936539.1
Coordinates 4029247..4029456 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP475_RS19705 4024623..4025426 - 804 WP_033649853.1 energy transducer TonB -
HP475_RS19710 4025529..4026368 - 840 WP_041038076.1 ChaN family lipoprotein -
HP475_RS19715 4026546..4027955 + 1410 WP_033654998.1 S-methylmethionine permease -
HP475_RS19720 4027945..4028883 + 939 WP_049233579.1 homocysteine S-methyltransferase -
HP475_RS19725 4028894..4029250 - 357 WP_033655000.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HP475_RS19730 4029247..4029456 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HP475_RS19735 4029566..4031845 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
HP475_RS19740 4032058..4032231 - 174 WP_033635476.1 hypothetical protein -
HP475_RS19745 4032212..4032592 - 381 WP_033635477.1 DUF2570 family protein -
HP475_RS19750 4032589..4032990 - 402 WP_021505638.1 M15 family metallopeptidase -
HP475_RS19755 4032980..4033306 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(20-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13086.82 Da        Isoelectric Point: 4.5654

>T158300 WP_033655000.1 NZ_CP053925:c4029250-4028894 [Serratia marcescens]
VIFLTAEDIAEFNAEIVPHGRQDGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGVALREDAELVEITVEAAQGRLNVEQAAEYLRLLTE

Download         Length: 357 bp

>T158300 NZ_CP069605:1862994-1863308 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT158300 WP_004936539.1 NZ_CP053925:c4029456-4029247 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT158300 NZ_CP069605:1862755-1862991 [Dickeya dianthicola]
ATGACCGCGAAACAGCGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGGTCCGGGCGCGTGAGGCGGG
CATTAACCTGAGTGCCACTCTGACAACCGCCCTGGATGCCGAGCTTCGCCGTCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGTTTTCATGATGAGCACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D5Y033

Antitoxin

Source ID Structure

References