Detailed information of TA system TA158299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3788185..3788711
• Replicon: chromosome
• Accession: NZ_CP053925
• Organism: Serratia marcescens strain 12/2010

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1EXL1
• Locus tag: HP475_RS18580
• Protein ID: WP_000323025.1
• Coordinates: 3788185..3788472 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: J5W3H0
• Locus tag: HP475_RS18585
• Protein ID: WP_004196370.1
• Coordinates: 3788472..3788711 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP475_RS18560	3784162..3786450	+	2289	WP_033635301.1	ribonucleoside-diphosphate reductase subunit alpha	-
HP475_RS18565	3786518..3787648	+	1131	WP_019453694.1	ribonucleotide-diphosphate reductase subunit beta	-
HP475_RS18570	3787652..3787912	+	261	WP_033635302.1	2Fe-2S ferredoxin-like protein	-
HP475_RS18575	3787972..3788124	-	153	WP_033635303.1	Hok/Gef family protein	-
HP475_RS18580	3788185..3788472	-	288	WP_000323025.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
HP475_RS18585	3788472..3788711	-	240	WP_004196370.1	type II toxin-antitoxin system antitoxin RelB	Antitoxin
HP475_RS18590	3788962..3789327	+	366	WP_009651956.1	hypothetical protein	-
HP475_RS18595	3789371..3790108	+	738	WP_008460272.1	HupE/UreJ family protein	-
HP475_RS18600	3790122..3790811	+	690	WP_004196322.1	hypothetical protein	-
HP475_RS18605	3790842..3792218	-	1377	WP_004196363.1	chromate efflux transporter	-
HP475_RS18610	3792175..3793152	-	978	WP_004196334.1	chromate resistance protein	-
HP475_RS18615	3793182..3793374	+	193	Protein_3635	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3788185..3802441	14256

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-79)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11225.22 Da
• Isoelectric Point: 10.1967

>T158299 WP_000323025.1 NZ_CP053925:c3788472-3788185 [Serratia marcescens]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Nucleotide

• Length: 288 bp

>T158299 NZ_CP069605:1628439-1628696 [Dickeya dianthicola]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9018.43 Da
• Isoelectric Point: 4.3894

>AT158299 WP_004196370.1 NZ_CP053925:c3788711-3788472 [Serratia marcescens]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Nucleotide

• Length: 240 bp

>AT158299 NZ_CP069605:1628704-1629192 [Dickeya dianthicola]
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG

Structures

Toxin

• PDB: 4V7K
• PDB: 4V7J
• PDB: 4FXI
• PDB: 4FXE
• PDB: 2KC8
• PDB: 4FXH
• PDB: 2KC9

Antitoxin

• AlphaFold DB: A0A2J4QRH4