Detailed information of TA system TA158288

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 890385..890911
• Replicon: chromosome
• Accession: NZ_CP053925
• Organism: Serratia marcescens strain 12/2010

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1EXL1
• Locus tag: HP475_RS04140
• Protein ID: WP_000323025.1
• Coordinates: 890385..890672 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: J5W3H0
• Locus tag: HP475_RS04145
• Protein ID: WP_004196370.1
• Coordinates: 890672..890911 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP475_RS04110	885852..886466	+	615	WP_049233708.1	methylthioribulose 1-phosphate dehydratase	-
HP475_RS04115	886463..887152	+	690	WP_049233710.1	acireductone synthase	-
HP475_RS04120	887149..887691	+	543	WP_015376726.1	acireductone dioxygenase ARD	-
HP475_RS04125	887709..888737	-	1029	WP_049233713.1	S-methyl-5-thioribose-1-phosphate isomerase	-
HP475_RS04130	888884..890083	+	1200	WP_049233715.1	S-methyl-5-thioribose kinase	-
HP475_RS04135	890157..890309	-	153	WP_004930217.1	Hok/Gef family protein	-
HP475_RS04140	890385..890672	-	288	WP_000323025.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
HP475_RS04145	890672..890911	-	240	WP_004196370.1	type II toxin-antitoxin system antitoxin RelB	Antitoxin
HP475_RS04150	891162..891527	+	366	WP_009651956.1	hypothetical protein	-
HP475_RS04155	891571..892308	+	738	WP_008460272.1	HupE/UreJ family protein	-
HP475_RS04160	892322..893011	+	690	WP_004196322.1	hypothetical protein	-
HP475_RS04165	893042..894418	-	1377	WP_004196363.1	chromate efflux transporter	-
HP475_RS04170	894375..895352	-	978	WP_004196334.1	chromate resistance protein	-
HP475_RS04175	895382..895574	+	193	Protein_792	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	890385..904643	14258

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-79)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11225.22 Da
• Isoelectric Point: 10.1967

>T158288 WP_000323025.1 NZ_CP053925:c890672-890385 [Serratia marcescens]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Nucleotide

• Length: 288 bp

>T158288 NZ_CP069604:1628439-1628696 [Dickeya dianthicola]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9018.43 Da
• Isoelectric Point: 4.3894

>AT158288 WP_004196370.1 NZ_CP053925:c890911-890672 [Serratia marcescens]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Nucleotide

• Length: 240 bp

>AT158288 NZ_CP069604:1628704-1629192 [Dickeya dianthicola]
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG

Structures

Toxin

• PDB: 4V7K
• PDB: 4V7J
• PDB: 4FXI
• PDB: 4FXE
• PDB: 2KC8
• PDB: 4FXH
• PDB: 2KC9

Antitoxin

• AlphaFold DB: A0A2J4QRH4