Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 193681..194153 Replicon chromosome
Accession NZ_CP053925
Organism Serratia marcescens strain 12/2010

Toxin (Protein)


Gene name relE Uniprot ID A0A7D5XNM9
Locus tag HP475_RS00910 Protein ID WP_049234387.1
Coordinates 193878..194153 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5XL40
Locus tag HP475_RS00905 Protein ID WP_049234388.1
Coordinates 193681..193878 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP475_RS00875 188874..190142 + 1269 WP_049234394.1 glycerol-3-phosphate dehydrogenase subunit GlpB -
HP475_RS00880 190139..191338 + 1200 WP_049234392.1 anaerobic glycerol-3-phosphate dehydrogenase subunit C -
HP475_RS00885 191374..191937 - 564 WP_033636670.1 DcrB family lipoprotein -
HP475_RS00890 192018..192452 - 435 WP_049234390.1 GNAT family N-acetyltransferase -
HP475_RS00895 192494..193153 - 660 WP_033636672.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
HP475_RS00900 193374..193619 + 246 WP_025304890.1 sulfurtransferase TusA -
HP475_RS00905 193681..193878 + 198 WP_049234388.1 hypothetical protein Antitoxin
HP475_RS00910 193878..194153 + 276 WP_049234387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HP475_RS00915 194213..196531 - 2319 WP_049234385.1 zinc/cadmium/mercury/lead-transporting ATPase -
HP475_RS00920 197213..198676 + 1464 WP_049234383.1 serralysin family metalloprotease -
HP475_RS00925 198732..199109 + 378 WP_038874139.1 AprI/Inh family metalloprotease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10680.59 Da        Isoelectric Point: 11.2806

>T158287 WP_049234387.1 NZ_CP053925:193878-194153 [Serratia marcescens]
MLNIEWTRAARQDLAEIVGFIANDNPLAARKMKVLIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Download         Length: 276 bp

>T158287 NZ_CP069604:1578334-1578648 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGCCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGGCGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7384.42 Da        Isoelectric Point: 4.2694

>AT158287 WP_049234388.1 NZ_CP053925:193681-193878 [Serratia marcescens]
MSILLLPTVANMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Download         Length: 198 bp

>AT158287 NZ_CP069604:1578095-1578331 [Dickeya dianthicola]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGCTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACCGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D5XNM9

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5XL40

References