Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 55605..56140 Replicon chromosome
Accession NZ_CP053925
Organism Serratia marcescens strain 12/2010

Toxin (Protein)


Gene name relE Uniprot ID A0A5C7D971
Locus tag HP475_RS00250 Protein ID WP_033636570.1
Coordinates 55865..56140 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D6BJ42
Locus tag HP475_RS00245 Protein ID WP_047569919.1
Coordinates 55605..55865 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP475_RS00225 50924..51574 + 651 WP_033636562.1 DcrB-related protein -
HP475_RS00230 51615..52220 + 606 WP_033636563.1 glutathione S-transferase -
HP475_RS00235 52290..53684 + 1395 WP_033649528.1 L-seryl-tRNA(Sec) selenium transferase -
HP475_RS00240 53681..55522 + 1842 WP_049235505.1 selenocysteine-specific translation elongation factor -
HP475_RS00245 55605..55865 + 261 WP_047569919.1 ribbon-helix-helix domain-containing protein Antitoxin
HP475_RS00250 55865..56140 + 276 WP_033636570.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HP475_RS00255 56152..57063 - 912 WP_033636572.1 LysR family transcriptional regulator -
HP475_RS00260 57185..57811 + 627 WP_049235504.1 LysE family translocator -
HP475_RS00265 57863..59110 - 1248 WP_033638635.1 MFS transporter -
HP475_RS00270 59328..60320 + 993 WP_049235503.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10578.32 Da        Isoelectric Point: 10.3377

>T158286 WP_033636570.1 NZ_CP053925:55865-56140 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T158286 NZ_CP069604:c1319880-1319344 [Dickeya dianthicola]
ATGGTAGATACTCAAAGTGAAAGTAATGGTGTAGTGGTATACGCGTATCAGGCAGATACCACATACCCTGGGAGTAAGAG
TTTCGATTGCGGAAATACCGTAATCAACTCTTTTGTGCGTAGCTCCCTCAAGAAAAGCGTCAGAGATGGGAATTGTGCAG
CTAAAGTATTGGTTAAAGATGAAACAAAAGAGCTGTTGGGTTTCTGTACTTTTGCTGCTTACTCTCTTGAAAAAAGTAAG
TTGGCGGGGGTGGTTTCAGGTTCATTGCCTCATGAATTAGGGGTTGTTCGGCTAATTATGCTGGGGGTAGCCACGAAAGA
ACAGAATAAAGGCTATGGACAAGAACTGCTTTTAGAATTCTTTAAACAGGTTAAAACCATCCACGAATCGCTACCTGTTA
AAGGCGTGTATTTGGATGCGGATCCGGCAGCAATTGACTTCTATATCCGGTTAGGTTTCGTTCAACTTAATGAACCACCG
AATGCTTTTGGTGCGGTGCCCATGTTTTTGGCCATTCAACATATCCTTGCTGCGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9683.98 Da        Isoelectric Point: 4.5084

>AT158286 WP_047569919.1 NZ_CP053925:55605-55865 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT158286 NZ_CP069604:c1320172-1319861 [Dickeya dianthicola]
ATGTCTAATGTATCAGTGTTTCCCAATGATATTCGCGTCACGAAGAACGCGCGGGTGGAGTTAAAAACTAGCCCTGACCT
TAAAGATGTGCTTCGTGAAGCAGCTACGGCTGCAGGTTTAGATTTGAGTGCGTTTATTCTTAATGCCGCCCTGGAGCGAG
CAGAAAGCGTCCTGGATAACCAGCGGCGCCGACAGCTTTCAGCAGCAAGCTGGCAACAATTAAACCAACTCTTGTCTGAA
CCTGCTGCACCGACGCTGGCTTTACAGGCGTTAATGCAGAGGAAGAAACAAGATGGTAGATACTCAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D971

Antitoxin

Source ID Structure
AlphaFold DB A0A7D6BJ42

References