Detailed information of TA system TA158277

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1480349..1481006
• Replicon: chromosome
• Accession: NZ_CP053922
• Organism: Pseudomonas aeruginosa strain YD001

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HQN50_RS06970
• Protein ID: WP_033971890.1
• Coordinates: 1480824..1481006 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HQN50_RS06965
• Protein ID: WP_003124172.1
• Coordinates: 1480349..1480777 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQN50_RS06925	1476404..1477105	+	702	WP_172792800.1	phage regulatory protein/antirepressor Ant	-
HQN50_RS06930	1477170..1477931	+	762	WP_172792801.1	helix-turn-helix domain-containing protein	-
HQN50_RS06935	1477928..1478611	+	684	WP_033991849.1	hypothetical protein	-
HQN50_RS06940	1478608..1478814	+	207	WP_003159465.1	hypothetical protein	-
HQN50_RS06945	1478811..1479182	+	372	WP_031630618.1	recombinase	-
HQN50_RS06950	1479179..1479526	+	348	WP_172792802.1	RusA family crossover junction endodeoxyribonuclease	-
HQN50_RS06955	1479523..1479822	+	300	WP_172792803.1	hypothetical protein	-
HQN50_RS06960	1479824..1480198	+	375	WP_121335454.1	hypothetical protein	-
HQN50_RS06965	1480349..1480777	-	429	WP_003124172.1	hypothetical protein	Antitoxin
HQN50_RS06970	1480824..1481006	-	183	WP_033971890.1	type II toxin-antitoxin system HicA family toxin	Toxin
HQN50_RS06975	1481207..1481521	+	315	WP_015649339.1	phage holin, lambda family	-
HQN50_RS06980	1481521..1482138	+	618	WP_172792804.1	glycoside hydrolase family 19 protein	-
HQN50_RS06985	1482138..1482608	+	471	WP_172792805.1	lysis system i-spanin subunit Rz	-
HQN50_RS06990	1482605..1483348	+	744	WP_003159066.1	hypothetical protein	-
HQN50_RS06995	1483468..1484013	+	546	WP_023083814.1	terminase small subunit	-
HQN50_RS07000	1483985..1485961	+	1977	WP_034059294.1	phage terminase large subunit family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1456717..1530451	73734

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-78)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6776.89 Da
• Isoelectric Point: 11.0775

>T158277 WP_033971890.1 NZ_CP053922:c1481006-1480824 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGTKEMPEPTRKAIIKQLGLK

Nucleotide

• Length: 183 bp

>T158277 NZ_CP069603:1628439-1628696 [Dickeya dianthicola]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15770.97 Da
• Isoelectric Point: 4.6562

>AT158277 WP_003124172.1 NZ_CP053922:c1480777-1480349 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KVALWNEMIRRDMRKADLCRLLGIAQIQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Nucleotide

• Length: 429 bp

>AT158277 NZ_CP069603:1628704-1629192 [Dickeya dianthicola]
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG