158276

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 149563..150068 Replicon chromosome
Accession NZ_CP053922
Organism Pseudomonas aeruginosa strain YD001

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag HQN50_RS00670 Protein ID WP_003121619.1
Coordinates 149563..149844 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HQN50_RS00675 Protein ID WP_003112628.1
Coordinates 149841..150068 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQN50_RS00645 144814..146163 + 1350 WP_073671016.1 C4-dicarboxylate transporter DctA -
HQN50_RS00650 146212..146898 + 687 WP_003083762.1 FadR family transcriptional regulator -
HQN50_RS00655 146999..147733 + 735 WP_003117208.1 GntR family transcriptional regulator -
HQN50_RS00660 147937..148323 + 387 WP_014602345.1 aegerolysin family protein -
HQN50_RS00665 148355..149263 - 909 WP_016561475.1 LysR family transcriptional regulator -
HQN50_RS00670 149563..149844 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
HQN50_RS00675 149841..150068 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HQN50_RS00680 150244..150864 - 621 WP_023088714.1 hypothetical protein -
HQN50_RS00685 150965..151465 + 501 WP_003101228.1 LEA type 2 family protein -
HQN50_RS00690 151538..151879 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HQN50_RS00695 151961..153388 - 1428 WP_003083784.1 GABA permease -
HQN50_RS00700 153557..155050 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T158276 WP_003121619.1 NZ_CP053922:c149844-149563 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T158276 NZ_CP069603:1578334-1578648 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGCCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGGCGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT158276 WP_003112628.1 NZ_CP053922:c150068-149841 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT158276 NZ_CP069603:1578095-1578331 [Dickeya dianthicola]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGCTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACCGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References