Detailed information of TA system TA158275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 5421611..5422650
• Replicon: chromosome
• Accession: NZ_CP053920
• Organism: Comamonas thiooxydans strain QYY

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: HQM26_RS25100
• Protein ID: WP_177341014.1
• Coordinates: 5421611..5422186 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: HQM26_RS25105
• Protein ID: WP_177341015.1
• Coordinates: 5422186..5422650 (-)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQM26_RS25090	5419873..5420943	-	1071	WP_177341013.1	IS110 family transposase	-
HQM26_RS25095	5421116..5421442	+	327	WP_177341136.1	helix-turn-helix domain-containing protein	-
HQM26_RS25100	5421611..5422186	-	576	WP_177341014.1	PIN domain-containing protein	Toxin
HQM26_RS25105	5422186..5422650	-	465	WP_177341015.1	helix-turn-helix domain-containing protein	Antitoxin
HQM26_RS25110	5423201..5424535	-	1335	WP_177341137.1	hypothetical protein	-
HQM26_RS25115	5424584..5425465	-	882	WP_177341016.1	ParB N-terminal domain-containing protein	-
HQM26_RS25120	5425462..5426364	-	903	WP_177341017.1	ParB/RepB/Spo0J family partition protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	5396934..5522787	125853

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21393.69 Da
• Isoelectric Point: 5.6378

>T158275 WP_177341014.1 NZ_CP053920:c5422186-5421611 [Comamonas thiooxydans]
MRSSPFTVVYDACVMYPAPLRSFLMYVSLEGCYRARWTAQIHDEWKRNLLKNRPDFTQEKLDKISSLMGQAVPDCLVTGY
DALINGLTLPDQDDRHVLAAAIRCGAGVIVTMNLKDLPPAALSQYGVEAQHPDEFLFDLMDLDLAAVLNAASKHRASLKN
PELTAQEYLDMLERQGLTQTCRKLAAYSLLI

Nucleotide

• Length: 576 bp

>T158275 NZ_CP069603:c1319880-1319344 [Dickeya dianthicola]
ATGGTAGATACTCAAAGTGAAAGTAATGGTGTAGTGGTATACGCGTATCAGGCAGATACCACATACCCTGGGAGTAAGAG
TTTCGATTGCGGAAATACCGTAATCAACTCTTTTGTGCGTAGCTCCCTCAAGAAAAGCGTCAGAGATGGGAATTGTGCAG
CTAAAGTATTGGTTAAAGATGAAACAAAAGAGCTGTTGGGTTTCTGTACTTTTGCTGCTTACTCTCTTGAAAAAAGTAAG
TTGGCGGGGGTGGTTTCAGGTTCATTGCCTCATGAATTAGGGGTTGTTCGGCTAATTATGCTGGGGGTAGCCACGAAAGA
ACAGAATAAAGGCTATGGACAAGAACTGCTTTTAGAATTCTTTAAACAGGTTAAAACCATCCACGAATCGCTACCTGTTA
AAGGCGTGTATTTGGATGCGGATCCGGCAGCAATTGACTTCTATATCCGGTTAGGTTTCGTTCAACTTAATGAACCACCG
AATGCTTTTGGTGCGGTGCCCATGTTTTTGGCCATTCAACATATCCTTGCTGCGTAG

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 16781.08 Da
• Isoelectric Point: 5.5804

>AT158275 WP_177341015.1 NZ_CP053920:c5422650-5422186 [Comamonas thiooxydans]
MNAIANDKVMLPHATEKQAATEGQRALAAYLSTKAETQLIQITSTDGQQHPIELPTSALRLLQEVLAELALGNAVKVVPV
HAELTTQEAADLLNVSRPYVVQLMESGELPFHKAGTHRRVKFSDLQAYKEKRDQSSAEAMTALSALDQELGMGY

Nucleotide

• Length: 465 bp

>AT158275 NZ_CP069603:c1320172-1319861 [Dickeya dianthicola]
ATGTCTAATGTATCAGTGTTTCCCAATGATATTCGCGTCACGAAGAACGCGCGGGTGGAGTTAAAAACTAGCCCTGACCT
TAAAGATGTGCTTCGTGAAGCAGCTACGGCTGCAGGTTTAGATTTGAGTGCGTTTATTCTTAATGCCGCCCTGGAGCGAG
CAGAAAGCGTCCTGGATAACCAGCGGCGCCGACAGCTTTCAGCAGCAAGCTGGCAACAATTAAACCAACTCTTGTCTGAA
CCTGCTGCACCGACGCTGGCTTTACAGGCGTTAATGCAGAGGAAGAAACAAGATGGTAGATACTCAAAGTGA