Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3307049..3308739 Replicon chromosome
Accession NZ_CP053920
Organism Comamonas thiooxydans strain QYY

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HQM26_RS15405 Protein ID WP_054074328.1
Coordinates 3307861..3308739 (-) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y8THJ5
Locus tag HQM26_RS15400 Protein ID WP_004340321.1
Coordinates 3307049..3307855 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQM26_RS15375 3302181..3303038 - 858 WP_012840239.1 IclR family transcriptional regulator -
HQM26_RS15380 3303046..3303822 - 777 WP_039050300.1 SDR family oxidoreductase -
HQM26_RS15385 3304137..3304895 - 759 WP_054074331.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
HQM26_RS15390 3305027..3306013 - 987 WP_054074330.1 tripartite tricarboxylate transporter substrate binding protein -
HQM26_RS15395 3306206..3307006 - 801 WP_054074329.1 aspartate dehydrogenase -
HQM26_RS15400 3307049..3307855 - 807 WP_004340321.1 IclR family transcriptional regulator Antitoxin
HQM26_RS15405 3307861..3308739 - 879 WP_054074328.1 alpha/beta hydrolase Toxin
HQM26_RS15410 3308748..3309281 - 534 WP_003072476.1 cupin domain-containing protein -
HQM26_RS15415 3309542..3311218 - 1677 WP_004340316.1 long-chain-fatty-acid--CoA ligase -
HQM26_RS15420 3311432..3312496 - 1065 WP_004340312.1 fructose-bisphosphate aldolase class II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(44-277)

Antitoxin

Transcription regulator IclR, C-terminal

(137-257)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 30628.14 Da        Isoelectric Point: 6.3787

>T158273 WP_054074328.1 NZ_CP053920:c3308739-3307861 [Comamonas thiooxydans]
MHEDLLSLKQQLLQTGFPEQLVKLPQKAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALLLGDKARVLAWDAPGYGV
STPLAQSAPADADYAQVLAQSLLVLGVRRCLLVGHSLGALMAARLAVTAAPGLVEQLVLISPAGGYGAPAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS

Download         Length: 879 bp

>T158273 NZ_CP069603:c988560-987904 [Dickeya dianthicola]
GTGGCCTATGACTACAGCGCCAATCTCAACCCGGAAAAGGCCCTTATCTGGCGCATTGTCCACCGGGACAACATCCCGTG
GATACTGGACAACGGTCTACACTGCGGCAACAGCCCGGTGCAGGCTGCAAACTGGATCAATATTGGTAACCCGGAGCTTA
TCAACAGACGCGCCGGGCACCCGGTGCCTGCCGGGGCGGGTGGTACGCTGCATGACTATGTGCCGTTTTACTTTACCCCC
TTCTCACCGATGCTGATGAATATCCACAGTGGGCGCGGCGGCATTAAGCAACGTCCCAACGAAGAAATCGTCATTCTGGT
CAGCAGCCTGCGACATGTGGCGATACAAAACGTCCCCTTCGTGTTTACCGACAGCCACGCCTACTATAATCTGGCGAATT
ACTATACCGATCTAAACAATCTGCACCGGATCGACTGGCCCATTTTACAGGCGCGGGATTTCCGTCGCGATCAGGACGAT
CTTGCCAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGCAGCACTGCCCCATCACGCTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAATGGCTGTCGCAACGCAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29259.22 Da        Isoelectric Point: 5.3811

>AT158273 WP_004340321.1 NZ_CP053920:c3307855-3307049 [Comamonas thiooxydans]
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNIDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR

Download         Length: 807 bp

>AT158273 NZ_CP069603:c987907-986840 [Dickeya dianthicola]
ATGATGACATATACACAAGGCAATTTACTGGACGCGCCCGTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGATAATATGAAAGCCTATGCACTCGCCTGTAAACAAAAGC
AGGTGACGACTGGCAAAATGTTTATCACTGAAACCGACGAGCTGATGGGGCCACGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCTCGCATGGAGTGGATTGAAGACGGCTTACAGGACTTACGTCGCTTTTTGATCGAAGAGAA
AGTGCAGTCCATCGCCATTCCTCCGCTGGGGGCGGGAAACGGCGGCCTGAACTGGTCGGACGTGCAGGCGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATCCTGATTTATGAGCCTACCGAAAAATACCAAAACGTCGCCAAGAGTACC
GGCGTAAAAAAGCTCACCCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCACCAGCAGGAGGACGTGCTAAAACTGC
GGTTTGAGGCACACAATTATGGCCCGTATGCCCCCAACCTGAACCATCTGCTTAACGCGCTGGACGGCACCTATCTGAAG
GCCGAGAAACGCATCCCGGACAGCCAGCCGCTGGACGTGATCTGGTTTAACGATCGGGAAAAAGAACACATTAATCTCTG
GCTGAATAACGAGGCCAAAGCGTGGCTACCGGCGCTTGAGCAGGTCAGCCAGTTGATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCGACCGTTGACTGGCTGCTGACCCGAGGAGAGTGCCAGCCCACGCTGGATTCCGTGAAAGAGGGG
CTACACCAGTGGCCTGCCGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTCTTTGACGACAAAAATCTGCAATTTGCCAT
AAACCGTGTCATGGAGTTCCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y8THJ5

References