Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 698975..700511 Replicon chromosome
Accession NZ_CP053920
Organism Comamonas thiooxydans strain QYY

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag HQM26_RS03105 Protein ID WP_012838314.1
Coordinates 699213..700511 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag HQM26_RS03100 Protein ID WP_012838313.1
Coordinates 698975..699223 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQM26_RS03085 695674..696549 + 876 WP_054074233.1 hypothetical protein -
HQM26_RS03090 696642..698480 + 1839 WP_054074234.1 dihydrolipoyl dehydrogenase -
HQM26_RS03095 698645..698803 + 159 WP_041744108.1 hypothetical protein -
HQM26_RS03100 698975..699223 + 249 WP_012838313.1 helix-turn-helix transcriptional regulator Antitoxin
HQM26_RS03105 699213..700511 + 1299 WP_012838314.1 type II toxin-antitoxin system HipA family toxin Toxin
HQM26_RS03110 700745..701221 + 477 WP_080692925.1 GFA family protein -
HQM26_RS03115 701354..702724 - 1371 WP_012838316.1 MFS transporter -
HQM26_RS03120 703572..703928 - 357 WP_054074235.1 alkylphosphonate utilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 676285..959357 283072


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-60)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 47029.09 Da        Isoelectric Point: 7.2921

>T158271 WP_012838314.1 NZ_CP053920:699213-700511 [Comamonas thiooxydans]
MTHELEVWLFDERVGSLSLVHGRLSFAYATDWLALPQATALSQSLPLQAKPFDDHQTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPQTNGAGATGAPGDVEWLSDQKLLALLDELPRRPMLAGDDGLRLSLAGAQD
KLPVVVDESIPGAVRIGLPRNGAPSSHILKPAIHAVEDSVANEGFCMLLAQVMGLRPANARIQSVLGRSFLLVKRYDREL
NAQDLHQPQLQRLHQEDFCQALGVVPELKYQNEGGPGLAQCFALLRSVTRPSAPQVLRLLDGAIFNALIGNHDAHGKNFS
LLYGGRAPVLAPFYDLLATAIYPQLTPKMAMKIGSKYKFSELEARHWEQFAEEAGLAKAATRKRLQQLANELPAAARKLQ
AAPPHGFAGNAVVTQIVQLIEQRCALTLRRLA

Download         Length: 1299 bp

>T158271 NZ_CP069603:733246-733677 [Dickeya dianthicola]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGCTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGTCGGACGGCTATGCGCCGCTGTGGTTGGGCCTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGTTCGGCGCCCGTGGGTAATGCGCAACGGCGTGTTGCTGTCATTGCGGGCAACGAATGGCAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGTAACGAAGAATGGCGGCTGTTGCGCCAACTGTTGCAGCAGCATCCGT
TGCAGGGAACCGAATCCTCCCGCCATCATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8529.72 Da        Isoelectric Point: 5.6051

>AT158271 WP_012838313.1 NZ_CP053920:698975-699223 [Comamonas thiooxydans]
MSTIQTTEQLGAALRTARKQLGLTQPQLALAAGVGTRFIVDLEAGKPTVRLEHVLRVIDALGGELQLGGLPNTASEGADH
DA

Download         Length: 249 bp

>AT158271 NZ_CP069603:732999-733265 [Dickeya dianthicola]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAATATGACACGCTGAGCGACGACGACAAGCTGCACTTCATTCGTCTGCTGCAGTGCGATGATCCCGACT
TGTTCAACTGGCTGATGAATCATGGCGAGCCGGTAGATCCGGCGCTGAAACGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References