Detailed information of TA system TA158270

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 5956550..5957770
• Replicon: chromosome
• Accession: NZ_CP053917
• Organism: Pseudomonas aeruginosa strain PSE6684

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HPT07_RS28210
• Protein ID: WP_003118970.1
• Coordinates: 5956550..5957128 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HPT07_RS28215
• Protein ID: WP_003132728.1
• Coordinates: 5957216..5957770 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPT07_RS28190	5951770..5951994	+	225	WP_010791890.1	hypothetical protein	-
HPT07_RS28195	5952053..5953102	+	1050	WP_033938087.1	TolC family protein	-
HPT07_RS28200	5953092..5955263	+	2172	WP_033989048.1	type I secretion system permease/ATPase	-
HPT07_RS28205	5955253..5956440	+	1188	WP_003110489.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HPT07_RS28210	5956550..5957128	-	579	WP_003118970.1	HD domain-containing protein	Toxin
HPT07_RS28215	5957216..5957770	-	555	WP_003132728.1	helix-turn-helix domain-containing protein	Antitoxin
HPT07_RS28220	5957928..5960123	-	2196	WP_033938086.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HPT07_RS28225	5960128..5960589	-	462	WP_003102736.1	(2Fe-2S)-binding protein	-
HPT07_RS28230	5960920..5961243	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
HPT07_RS28235	5961256..5961654	+	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
HPT07_RS28240	5961651..5962202	-	552	WP_003132721.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	5913384..5965253	51869

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21899.72 Da
• Isoelectric Point: 5.3655

>T158270 WP_003118970.1 NZ_CP053917:c5957128-5956550 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T158270 NZ_CP069603:c474341-473862 [Dickeya dianthicola]
GTGGGAATAACGGCACCTGAATTATTGCTGCCTCAACATGCGGTTGTGGATTTTCATTGTTCAGAGCCGTCATTGAATGA
ATGGCTGAAACGCAAGGCGTTAAAAAATCAGACGCTGGGCGCTTCACGCACCTTCGTGGTGTGTGAAGCCGGTACACAGC
GTGTGGTGGGGTTCTATGCCCTCGCGTCGGGCAGCATCCAGCGTCAGGTTGCGCCGGGCGCATTCCGGCGCAATATGCCT
GACCCCATTCCTGTTCTGGTGCTCGGTAGATTAGCCGTTGATGAACGTTATCAACGTATGGGGATCGGTGCCGGGCTCCT
GAAAGATGCGGTACTCCGCTCCCGCAATGTAGCGCAGCAGGTAGGCAACAAAGCGTTATTGGTACATGCGTTATCTGATG
AGGCAAAAGCGTTCTACCAATACTGGGGTTTTGTCCCGTCAGAAATACAGGAACACACCTTATTATTATCGTTATGGTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20470.63 Da
• Isoelectric Point: 8.1590

>AT158270 WP_003132728.1 NZ_CP053917:c5957770-5957216 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT158270 NZ_CP069603:c474604-474332 [Dickeya dianthicola]
ATGCGAACAGAGACAAAAGAAACGCCGATTAATATTCGTGCTAAAGCATCACAGCGGGAGCTGATTGATGTCGCCGCTAA
ATTGCTGTCGAAATCAAGAACAGAGTTTATCCTTGATGCTGCCTGCCGTGAGGCTGAGGATGTGTTGTTGGATCAAAGGC
TGTTTCTGGTCAATGATGAACAATATGATGCTTTCATTCAGGTGCTGGAATCACCTGTCACAGATAATCCGCGTATGAAT
GCATTACTGAACAGGAAATCTCCGTGGGAATAA