Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PfiT-PfiA/ParE(toxin) |
| Location | 4542452..4543060 | Replicon | chromosome |
| Accession | NZ_CP053917 | ||
| Organism | Pseudomonas aeruginosa strain PSE6684 | ||
Toxin (Protein)
| Gene name | PfiT | Uniprot ID | A0A444LUU5 |
| Locus tag | HPT07_RS21360 | Protein ID | WP_019486378.1 |
| Coordinates | 4542713..4543060 (+) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | PfiA | Uniprot ID | A0A0B0C355 |
| Locus tag | HPT07_RS21355 | Protein ID | WP_003114155.1 |
| Coordinates | 4542452..4542703 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPT07_RS21335 | 4538090..4538446 | + | 357 | WP_003114150.1 | DUF2523 domain-containing protein | - |
| HPT07_RS21340 | 4538450..4539733 | + | 1284 | WP_023124144.1 | zonular occludens toxin family protein | - |
| HPT07_RS21345 | 4539963..4541255 | + | 1293 | WP_003123045.1 | hypothetical protein | - |
| HPT07_RS21350 | 4541255..4542238 | + | 984 | WP_003114154.1 | tyrosine-type recombinase/integrase | - |
| HPT07_RS21355 | 4542452..4542703 | + | 252 | WP_003114155.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPT07_RS21360 | 4542713..4543060 | + | 348 | WP_019486378.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPT07_RS21365 | 4543379..4544581 | + | 1203 | WP_033989514.1 | integrase family protein | - |
| HPT07_RS21370 | 4544597..4545217 | + | 621 | WP_124123600.1 | hypothetical protein | - |
| HPT07_RS21375 | 4545214..4545420 | - | 207 | WP_033989513.1 | AlpA family phage regulatory protein | - |
| HPT07_RS21380 | 4545410..4545814 | - | 405 | WP_033989511.1 | hypothetical protein | - |
| HPT07_RS21385 | 4545811..4546194 | - | 384 | WP_033989510.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | catB7 | - | 4515266..4584068 | 68802 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 12956.72 Da Isoelectric Point: 4.4212
>T158268 WP_019486378.1 NZ_CP053917:4542713-4543060 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE
Download Length: 348 bp
>T158268 NZ_CP069602:c2266757-2266677 [Dickeya dianthicola]
AATGCCAACTTTTAGCGCACGGCTCTCTCCAAAGAGCCATTTCCCTAGACCGGGCACAGGAATCGTGTTCGGTCTTTTTT
T
AATGCCAACTTTTAGCGCACGGCTCTCTCCAAAGAGCCATTTCCCTAGACCGGGCACAGGAATCGTGTTCGGTCTTTTTT
T
Antitoxin
Download Length: 84 a.a. Molecular weight: 9442.79 Da Isoelectric Point: 9.4808
>AT158268 WP_003114155.1 NZ_CP053917:4542452-4542703 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE
Download Length: 252 bp
>AT158268 NZ_CP069602:2266675-2266757 [Dickeya dianthicola]
ATAAAAAAAGACCGAACACGATTCCTGTGCCCGGTCTAGGGAAATGGCTCTTTGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATT
ATAAAAAAAGACCGAACACGATTCCTGTGCCCGGTCTAGGGAAATGGCTCTTTGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A444LUU5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0B0C355 |