Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 2704148..2704653 | Replicon | chromosome |
| Accession | NZ_CP053917 | ||
| Organism | Pseudomonas aeruginosa strain PSE6684 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | V6A7K8 |
| Locus tag | HPT07_RS12940 | Protein ID | WP_003083773.1 |
| Coordinates | 2704372..2704653 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A1C7BDS9 |
| Locus tag | HPT07_RS12935 | Protein ID | WP_003083775.1 |
| Coordinates | 2704148..2704375 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPT07_RS12910 | 2699166..2700659 | + | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
| HPT07_RS12915 | 2700828..2702255 | + | 1428 | WP_003083784.1 | GABA permease | - |
| HPT07_RS12920 | 2702337..2702678 | - | 342 | WP_003101229.1 | alkylphosphonate utilization protein | - |
| HPT07_RS12925 | 2702751..2703251 | - | 501 | WP_003162763.1 | LEA type 2 family protein | - |
| HPT07_RS12930 | 2703352..2703972 | + | 621 | WP_003101226.1 | hypothetical protein | - |
| HPT07_RS12935 | 2704148..2704375 | + | 228 | WP_003083775.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| HPT07_RS12940 | 2704372..2704653 | + | 282 | WP_003083773.1 | type II toxin-antitoxin system toxin ParE | Toxin |
| HPT07_RS12945 | 2704953..2705861 | + | 909 | WP_003083769.1 | LysR family transcriptional regulator | - |
| HPT07_RS12950 | 2705893..2706279 | - | 387 | WP_003083767.1 | aegerolysin family protein | - |
| HPT07_RS12955 | 2706483..2707217 | - | 735 | WP_003110658.1 | GntR family transcriptional regulator | - |
| HPT07_RS12960 | 2707318..2708004 | - | 687 | WP_003083762.1 | FadR family transcriptional regulator | - |
| HPT07_RS12965 | 2708053..2709402 | - | 1350 | WP_003119513.1 | C4-dicarboxylate transporter DctA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | qnrVC1 / aadA11 / sul1 | vgrG1b / vgrG1a / clpV1 / hsiH1 / hsiG1 / hsiF1 / hsiE1 / hcp1 / hsiC1/vipB / hsiB1/vipA / hsiA1 / fha1 / lip1 / hsiJ1 / dotU1 / icmF1/tssM1 / tagF/pppB / pppA / ppkA / tagT / tagS / tagR / tagQ / phzH / exoT | 2695593..2961744 | 266151 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10462.19 Da Isoelectric Point: 10.0435
>T158266 WP_003083773.1 NZ_CP053917:2704372-2704653 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T158266 NZ_CP069602:1628439-1628696 [Dickeya dianthicola]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8556.58 Da Isoelectric Point: 5.5740
>AT158266 WP_003083775.1 NZ_CP053917:2704148-2704375 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
Download Length: 228 bp
>AT158266 NZ_CP069602:1628704-1629192 [Dickeya dianthicola]
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|