Detailed information of TA system TA158265

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 1267841..1269536
• Replicon: chromosome
• Accession: NZ_CP053917
• Organism: Pseudomonas aeruginosa strain PSE6684

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q9HYA0
• Locus tag: HPT07_RS06270
• Protein ID: WP_003112901.1
• Coordinates: 1268667..1269536 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: Q9HYA1
• Locus tag: HPT07_RS06265
• Protein ID: WP_003112902.1
• Coordinates: 1267841..1268674 (-)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPT07_RS06245	1263072..1264556	-	1485	WP_023102925.1	aldehyde dehydrogenase	-
HPT07_RS06250	1264568..1265371	-	804	WP_003130116.1	aspartate dehydrogenase	-
HPT07_RS06255	1265382..1267064	-	1683	WP_003130114.1	thiamine pyrophosphate-binding protein	-
HPT07_RS06260	1267057..1267854	-	798	WP_023111480.1	SDR family oxidoreductase	-
HPT07_RS06265	1267841..1268674	-	834	WP_003112902.1	IclR family transcriptional regulator	Antitoxin
HPT07_RS06270	1268667..1269536	-	870	WP_003112901.1	alpha/beta hydrolase	Toxin
HPT07_RS06275	1269545..1270075	-	531	WP_003112900.1	cupin domain-containing protein	-
HPT07_RS06280	1270089..1270850	-	762	WP_003112899.1	SDR family oxidoreductase	-
HPT07_RS06285	1270856..1271632	-	777	WP_003112898.1	ABC transporter permease	-
HPT07_RS06290	1271629..1272636	-	1008	WP_023097315.1	ABC transporter substrate-binding protein	-
HPT07_RS06295	1272677..1273528	-	852	WP_003130104.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (41-272)

Antitoxin

• Transcription regulator IclR, N-terminal (16-66)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30403.60 Da
• Isoelectric Point: 6.5894

>T158265 WP_003112901.1 NZ_CP053917:c1269536-1268667 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Nucleotide

• Length: 870 bp

>T158265 NZ_CP069602:1578334-1578648 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGCCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGGCGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30877.26 Da
• Isoelectric Point: 5.7725

>AT158265 WP_003112902.1 NZ_CP053917:c1268674-1267841 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Nucleotide

• Length: 834 bp

>AT158265 NZ_CP069602:1578095-1578331 [Dickeya dianthicola]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGCTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACCGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Structures

Toxin

• AlphaFold DB: Q9HYA0

Antitoxin

• AlphaFold DB: Q9HYA1