Detailed information of TA system TA158255

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 4234870..4235623
• Replicon: chromosome
• Accession: NZ_CP053896
• Organism: Providencia rettgeri strain YPR31

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HRD55_RS19520
• Protein ID: WP_096864327.1
• Coordinates: 4235189..4235623 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HRD55_RS19515
• Protein ID: WP_004905885.1
• Coordinates: 4234870..4235199 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRD55_RS19500	4230815..4231786	-	972	WP_004905881.1	efflux RND transporter periplasmic adaptor subunit	-
HRD55_RS19505	4232444..4234129	+	1686	WP_004905883.1	sensor histidine kinase	-
HRD55_RS19510	4234149..4234865	+	717	WP_004905884.1	two-component system response regulator BtsR	-
HRD55_RS19515	4234870..4235199	-	330	WP_004905885.1	helix-turn-helix domain-containing protein	Antitoxin
HRD55_RS19520	4235189..4235623	-	435	WP_096864327.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HRD55_RS19525	4235732..4237663	-	1932	WP_004905887.1	DEAD/DEAH family ATP-dependent RNA helicase	-
HRD55_RS19530	4237834..4238700	-	867	WP_004905888.1	lipoprotein NlpI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (19-139)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-93)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16141.82 Da
• Isoelectric Point: 9.3330

>T158255 WP_096864327.1 NZ_CP053896:c4235623-4235189 [Providencia rettgeri]
MALATIVIGTTWRVVVAFYKISSFKRSTKKIKIMDKHLLKAANEVLAGVYEADLGSGVIKKRIAINGKGKSGGVRVIIFF
KVSHHLFFADGWEKCNIAAKGVKEIEDDELDAYKNLSRLFLNYTDDKIADLVLHNILEELTDEQ

Nucleotide

• Length: 435 bp

>T158255 NZ_CP069601:1628439-1628696 [Dickeya dianthicola]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12235.50 Da
• Isoelectric Point: 10.3803

>AT158255 WP_004905885.1 NZ_CP053896:c4235199-4234870 [Providencia rettgeri]
MSNKLENMLELAKELHQVDAAPKSLVTDLEQKVGNRKINNKIKVVPMMSGAQIKQLRAQYGMSQAMLALALGMSKESVSK
WEREEKKPSGPALRMLHLIEQRGPEILII

Nucleotide

• Length: 330 bp

>AT158255 NZ_CP069601:1628704-1629192 [Dickeya dianthicola]
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG