Detailed information of TA system TA158253

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3041162..3041697
• Replicon: chromosome
• Accession: NZ_CP053896
• Organism: Providencia rettgeri strain YPR31

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: HRD55_RS14020
• Protein ID: WP_140170723.1
• Coordinates: 3041389..3041697 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: D4BV21
• Locus tag: HRD55_RS14015
• Protein ID: WP_004255691.1
• Coordinates: 3041162..3041389 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRD55_RS13995	3036444..3036884	+	441	WP_172767300.1	flagellar export chaperone FlgN	-
HRD55_RS14000	3037071..3037502	+	432	WP_140170720.1	hypothetical protein	-
HRD55_RS14005	3037655..3039754	-	2100	WP_004255687.1	flagellar biosynthesis protein FlhA	-
HRD55_RS14010	3039747..3040898	-	1152	WP_172767301.1	flagellar type III secretion system protein FlhB	-
HRD55_RS14015	3041162..3041389	+	228	WP_004255691.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HRD55_RS14020	3041389..3041697	+	309	WP_140170723.1	CcdB family protein	Toxin
HRD55_RS14025	3041713..3042270	+	558	WP_172767302.1	hypothetical protein	-
HRD55_RS14030	3042313..3042546	-	234	WP_080544466.1	helix-turn-helix domain-containing protein	-
HRD55_RS14035	3042717..3043355	-	639	WP_004255702.1	protein phosphatase CheZ	-
HRD55_RS14040	3043380..3043772	-	393	WP_004255705.1	chemotaxis response regulator CheY	-
HRD55_RS14045	3043814..3044881	-	1068	WP_094961164.1	chemotaxis response regulator protein-glutamate methylesterase	-
HRD55_RS14050	3044881..3045717	-	837	WP_004255713.1	chemotaxis protein-glutamate O-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (5-75)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11770.87 Da
• Isoelectric Point: 8.0469

>T158253 WP_140170723.1 NZ_CP053896:3041389-3041697 [Providencia rettgeri]
MQYRLYQNRDDAIKYPYLLDIQSNIIDLLNTRLVIPLFDSRLVKKPLPARLNPQLVINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Nucleotide

• Length: 309 bp

>T158253 NZ_CP069601:c1319880-1319344 [Dickeya dianthicola]
ATGGTAGATACTCAAAGTGAAAGTAATGGTGTAGTGGTATACGCGTATCAGGCAGATACCACATACCCTGGGAGTAAGAG
TTTCGATTGCGGAAATACCGTAATCAACTCTTTTGTGCGTAGCTCCCTCAAGAAAAGCGTCAGAGATGGGAATTGTGCAG
CTAAAGTATTGGTTAAAGATGAAACAAAAGAGCTGTTGGGTTTCTGTACTTTTGCTGCTTACTCTCTTGAAAAAAGTAAG
TTGGCGGGGGTGGTTTCAGGTTCATTGCCTCATGAATTAGGGGTTGTTCGGCTAATTATGCTGGGGGTAGCCACGAAAGA
ACAGAATAAAGGCTATGGACAAGAACTGCTTTTAGAATTCTTTAAACAGGTTAAAACCATCCACGAATCGCTACCTGTTA
AAGGCGTGTATTTGGATGCGGATCCGGCAGCAATTGACTTCTATATCCGGTTAGGTTTCGTTCAACTTAATGAACCACCG
AATGCTTTTGGTGCGGTGCCCATGTTTTTGGCCATTCAACATATCCTTGCTGCGTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8688.92 Da
• Isoelectric Point: 8.9375

>AT158253 WP_004255691.1 NZ_CP053896:3041162-3041389 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNVEGFNELNRINEEYGLLSDKYKDF

Nucleotide

• Length: 228 bp

>AT158253 NZ_CP069601:c1320172-1319861 [Dickeya dianthicola]
ATGTCTAATGTATCAGTGTTTCCCAATGATATTCGCGTCACGAAGAACGCGCGGGTGGAGTTAAAAACTAGCCCTGACCT
TAAAGATGTGCTTCGTGAAGCAGCTACGGCTGCAGGTTTAGATTTGAGTGCGTTTATTCTTAATGCCGCCCTGGAGCGAG
CAGAAAGCGTCCTGGATAACCAGCGGCGCCGACAGCTTTCAGCAGCAAGCTGGCAACAATTAAACCAACTCTTGTCTGAA
CCTGCTGCACCGACGCTGGCTTTACAGGCGTTAATGCAGAGGAAGAAACAAGATGGTAGATACTCAAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A6G6Q922