Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 883400..884046 Replicon chromosome
Accession NZ_CP053896
Organism Providencia rettgeri strain YPR31

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag HRD55_RS03795 Protein ID WP_004905417.1
Coordinates 883400..883603 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag HRD55_RS03800 Protein ID WP_004905413.1
Coordinates 883678..884046 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD55_RS03770 879476..879814 + 339 WP_004905421.1 P-II family nitrogen regulator -
HRD55_RS03775 879825..881111 + 1287 WP_172766823.1 ammonium transporter AmtB -
HRD55_RS03780 881250..882119 - 870 WP_096864792.1 acyl-CoA thioesterase II -
HRD55_RS03785 882358..882816 + 459 WP_004905418.1 YbaY family lipoprotein -
HRD55_RS03795 883400..883603 - 204 WP_004905417.1 hemolysin expression modulator Hha Toxin
HRD55_RS03800 883678..884046 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
HRD55_RS03805 884570..885940 - 1371 WP_172766824.1 murein transglycosylase D -
HRD55_RS03810 886022..886777 - 756 WP_004905408.1 hydroxyacylglutathione hydrolase -
HRD55_RS03815 886818..887552 + 735 WP_164564618.1 methyltransferase domain-containing protein -
HRD55_RS03820 887549..888019 - 471 WP_004905405.1 ribonuclease HI -
HRD55_RS03825 888074..888817 + 744 WP_004905404.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T158249 WP_004905417.1 NZ_CP053896:c883603-883400 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T158249 NZ_CP069601:733246-733677 [Dickeya dianthicola]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGCTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGTCGGACGGCTATGCGCCGCTGTGGTTGGGCCTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGTTCGGCGCCCGTGGGTAATGCGCAACGGCGTGTTGCTGTCATTGCGGGCAACGAATGGCAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGTAACGAAGAATGGCGGCTGTTGCGCCAACTGTTGCAGCAGCATCCGT
TGCAGGGAACCGAATCCTCCCGCCATCATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT158249 WP_004905413.1 NZ_CP053896:c884046-883678 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT158249 NZ_CP069601:732999-733265 [Dickeya dianthicola]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAATATGACACGCTGAGCGACGACGACAAGCTGCACTTCATTCGTCTGCTGCAGTGCGATGATCCCGACT
TGTTCAACTGGCTGATGAATCATGGCGAGCCGGTAGATCCGGCGCTGAAACGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References