Detailed information of TA system TA158247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3945900..3947471
• Replicon: chromosome
• Accession: NZ_CP053894
• Organism: Proteus mirabilis strain JPM24

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HRD54_RS18140
• Protein ID: WP_104731898.1
• Coordinates: 3945900..3947213 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: HRD54_RS18145
• Protein ID: WP_004249771.1
• Coordinates: 3947214..3947471 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRD54_RS18120	3941070..3941873	+	804	WP_004249775.1	energy transducer TonB	-
HRD54_RS18125	3941927..3943888	-	1962	WP_172764490.1	hypothetical protein	-
HRD54_RS18130	3943920..3944849	-	930	WP_004246518.1	metallophosphoesterase	-
HRD54_RS18135	3945034..3945498	-	465	WP_004246516.1	DUF1097 domain-containing protein	-
HRD54_RS18140	3945900..3947213	-	1314	WP_104731898.1	type II toxin-antitoxin system HipA family toxin	Toxin
HRD54_RS18145	3947214..3947471	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
HRD54_RS18150	3947747..3948376	-	630	WP_001145449.1	hypothetical protein	-
HRD54_RS18155	3948519..3948584	+	66	Protein_3521	EAL domain-containing protein	-
HRD54_RS18160	3948724..3949488	-	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
HRD54_RS18165	3949606..3949674	-	69	Protein_3523	EAL domain-containing protein	-
HRD54_RS18170	3949995..3950495	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
HRD54_RS18175	3950623..3951461	-	839	Protein_3525	sulfonamide-resistant dihydropteroate synthase Sul1	-
HRD54_RS18180	3951455..3951802	-	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49697.85 Da
• Isoelectric Point: 6.6588

>T158247 WP_104731898.1 NZ_CP053894:c3947213-3945900 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDVKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T158247 NZ_CP069600:2369367-2369837 [Dickeya dianthicola]
TTGATTCTCTACAGGCTGACCAAGACAAAATATCTTTCTACAGTCTGGACGGGATATGGGGCAAAAGAGGCAGGAGGTCG
CTGGAACAGTGTAGGTGTCTCGATGGTATATGTGTCTGAAACAGCATCGCTTACGATGCTTGAGACGCTTGTACATCTGC
ATGCTGCACATATTCTGGATTATTATACTCTGCTGCGTATTGATGTCCCTGATGACCATATTCAGAGCGTCAATATGAAC
GACTTGCCAGAAAATTGGGCTGAAGAAGACGCGCCGCCTGAGCTTGCTGCTTACGGTGATGCTTGGTGCTTTACCAAAAG
TTCGATAGCCTTGCGTGTCCCCAGCACTTTATCTCCCGTGGAATTTAACTACCTTTTAAACCCCGAGCACCCTGACTTCT
CCTCGATCATCCAGAACGCTGACACCATTCCGTTCCAGTTTGATAGCAGGCTGAAACCGGCGATTAAATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT158247 WP_004249771.1 NZ_CP053894:c3947471-3947214 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT158247 NZ_CP069600:2368927-2369370 [Dickeya dianthicola]
ATGAAAACATTTAGCTTATCCACGACACAGACCCGGCCGCCACGCTTGTGGCAGGTTGCGGGGTTAAACAATTCTGATGG
TGTAGCACTGCTGGGCCAGATTAACGAAGGCCTTGATGGCACAGTTGCAAACGTGATCATTGACTGGGCAAAGATCACGC
AGAACGACCTGCGCAAAATGTCCGGTATACCGTCCACGACATTCAGTCGTAGCCGGAAAGCCCGATTCACCGCCGACCAA
AGTGAGCGACTGGTGCGCATTATTCGCGTTATAGATCGGGCTGTAGAACTGTTCGAGGGTGATAAAGACGAGGCCCAGAA
ATGGTTGAATGAGCCAAACAGAGCACTGAGCTGGAAAGTGCCAGCGGAACTGATGGCCTCCGAAACCGGCGCTTACGAGG
TCATGAAATTGATTACACGCCTGGAGCATGGGGCATACTCTTGA

Structures

Antitoxin

• AlphaFold DB: B4F0T9