Detailed information of TA system TA158245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 12431..13032
• Replicon: chromosome
• Accession: NZ_CP053894
• Organism: Proteus mirabilis strain JPM24

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: HRD54_RS00055
• Protein ID: WP_049196622.1
• Coordinates: 12431..12814 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: HRD54_RS00060
• Protein ID: WP_004246496.1
• Coordinates: 12811..13032 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRD54_RS00030	7730..8299	+	570	WP_004249768.1	methyltransferase	-
HRD54_RS00035	8355..9842	-	1488	WP_150452831.1	PLP-dependent aminotransferase family protein	-
HRD54_RS00040	9971..10429	+	459	WP_150452832.1	GNAT family N-acetyltransferase	-
HRD54_RS00045	10525..11262	-	738	WP_004249950.1	sel1 repeat family protein	-
HRD54_RS00050	11371..12270	+	900	WP_063108742.1	N-acetylmuramic acid 6-phosphate etherase	-
HRD54_RS00055	12431..12814	-	384	WP_049196622.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HRD54_RS00060	12811..13032	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HRD54_RS00065	13636..13926	+	291	WP_152134550.1	helix-turn-helix domain-containing protein	-
HRD54_RS00070	13916..15265	+	1350	WP_172764398.1	type II toxin-antitoxin system HipA family toxin	-
HRD54_RS00075	15568..15882	-	315	WP_012518681.1	helix-turn-helix domain-containing protein	-
HRD54_RS00080	16362..16604	+	243	WP_017043889.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	12431..36493	24062

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14529.57 Da
• Isoelectric Point: 7.4005

>T158245 WP_049196622.1 NZ_CP053894:c12814-12431 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T158245 NZ_CP069600:1862994-1863308 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT158245 WP_004246496.1 NZ_CP053894:c13032-12811 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT158245 NZ_CP069600:1862755-1862991 [Dickeya dianthicola]
ATGACCGCGAAACAGCGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGGTCCGGGCGCGTGAGGCGGG
CATTAACCTGAGTGCCACTCTGACAACCGCCCTGGATGCCGAGCTTCGCCGTCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGTTTTCATGATGAGCACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9