Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2041951..2042575 Replicon chromosome
Accession NZ_CP053891
Organism Streptococcus agalactiae strain GBS20

Toxin (Protein)


Gene name parE Uniprot ID A0A076ZDW1
Locus tag HQ616_RS10320 Protein ID WP_000253103.1
Coordinates 2041951..2042298 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag HQ616_RS10325 Protein ID WP_000543070.1
Coordinates 2042288..2042575 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ616_RS10300 (HQ616_10240) 2037666..2038022 - 357 WP_000105934.1 DUF1304 domain-containing protein -
HQ616_RS10305 (HQ616_10245) 2038089..2040407 - 2319 WP_000883414.1 YhgE/Pip domain-containing protein -
HQ616_RS10310 (HQ616_10250) 2040546..2041085 + 540 WP_000245858.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
HQ616_RS10315 (HQ616_10255) 2041171..2041467 - 297 WP_001052249.1 DUF4298 domain-containing protein -
HQ616_RS10320 (HQ616_10260) 2041951..2042298 - 348 WP_000253103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ616_RS10325 (HQ616_10265) 2042288..2042575 - 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HQ616_RS10330 (HQ616_10270) 2042644..2043021 - 378 WP_000038826.1 ArpU family phage packaging/lysis transcriptional regulator -
HQ616_RS10335 (HQ616_10275) 2042996..2043148 - 153 Protein_1971 DUF1492 domain-containing protein -
HQ616_RS10340 (HQ616_10280) 2043155..2043643 - 489 WP_000891151.1 hypothetical protein -
HQ616_RS10345 (HQ616_10285) 2043716..2044273 - 558 WP_001258765.1 hypothetical protein -
HQ616_RS10350 (HQ616_10290) 2044431..2044604 - 174 WP_000694573.1 hypothetical protein -
HQ616_RS10355 (HQ616_10295) 2044601..2044858 - 258 WP_001069293.1 hypothetical protein -
HQ616_RS10360 (HQ616_10300) 2045151..2046545 - 1395 WP_000656430.1 VapE family protein -
HQ616_RS10365 (HQ616_10305) 2046557..2047414 - 858 WP_001029296.1 primase alpha helix C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2041171..2055749 14578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 5.1643

>T158244 WP_000253103.1 NZ_CP053891:c2042298-2041951 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Download         Length: 348 bp

>T158244 NZ_CP069600:1628439-1628696 [Dickeya dianthicola]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT158244 WP_000543070.1 NZ_CP053891:c2042575-2042288 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp

>AT158244 NZ_CP069600:1628704-1629192 [Dickeya dianthicola]
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076ZDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References