Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 239183..239795 Replicon chromosome
Accession NZ_CP053891
Organism Streptococcus agalactiae strain GBS20

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag HQ616_RS01415 Protein ID WP_000384858.1
Coordinates 239183..239518 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag HQ616_RS01420 Protein ID WP_000255538.1
Coordinates 239508..239795 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ616_RS01390 (HQ616_01385) 234381..235010 + 630 WP_000591148.1 hypothetical protein -
HQ616_RS01395 (HQ616_01390) 235323..236198 + 876 WP_000770113.1 hypothetical protein -
HQ616_RS01400 (HQ616_01395) 236234..236668 + 435 WP_001220479.1 hypothetical protein -
HQ616_RS01405 (HQ616_01400) 236984..238240 + 1257 WP_000122832.1 MobV family relaxase -
HQ616_RS01410 (HQ616_01405) 238408..238878 + 471 WP_000130119.1 hypothetical protein -
HQ616_RS01415 (HQ616_01410) 239183..239518 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ616_RS01420 (HQ616_01415) 239508..239795 - 288 WP_000255538.1 hypothetical protein Antitoxin
HQ616_RS01425 (HQ616_01420) 240198..241418 - 1221 WP_000156558.1 site-specific integrase -
HQ616_RS01430 (HQ616_01425) 241479..241739 - 261 WP_001196072.1 helix-turn-helix domain-containing protein -
HQ616_RS01435 (HQ616_01430) 241751..242497 - 747 WP_000966632.1 hypothetical protein -
HQ616_RS01440 (HQ616_01435) 242683..243474 - 792 WP_001868842.1 hypothetical protein -
HQ616_RS01445 (HQ616_01440) 243455..243988 - 534 WP_000680721.1 hypothetical protein -
HQ616_RS01450 (HQ616_01445) 243988..244326 - 339 WP_001187920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 190965..241523 50558


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T158243 WP_000384858.1 NZ_CP053891:c239518-239183 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T158243 NZ_CP069600:1578334-1578648 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGCCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGGCGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT158243 WP_000255538.1 NZ_CP053891:c239795-239508 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT158243 NZ_CP069600:1578095-1578331 [Dickeya dianthicola]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGCTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACCGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References