Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2058492..2059116 Replicon chromosome
Accession NZ_CP053890
Organism Streptococcus agalactiae strain GBS68

Toxin (Protein)


Gene name parE Uniprot ID A0A076ZDW1
Locus tag HQ618_RS10410 Protein ID WP_000253103.1
Coordinates 2058492..2058839 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag HQ618_RS10415 Protein ID WP_000543070.1
Coordinates 2058829..2059116 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ618_RS10390 (HQ618_10335) 2054207..2054563 - 357 WP_000105934.1 DUF1304 domain-containing protein -
HQ618_RS10395 (HQ618_10340) 2054630..2056948 - 2319 WP_000883414.1 YhgE/Pip domain-containing protein -
HQ618_RS10400 (HQ618_10345) 2057087..2057626 + 540 WP_000245858.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
HQ618_RS10405 (HQ618_10350) 2057712..2058008 - 297 WP_001052249.1 DUF4298 domain-containing protein -
HQ618_RS10410 (HQ618_10355) 2058492..2058839 - 348 WP_000253103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ618_RS10415 (HQ618_10360) 2058829..2059116 - 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HQ618_RS10420 (HQ618_10365) 2059185..2059562 - 378 WP_000038826.1 ArpU family phage packaging/lysis transcriptional regulator -
HQ618_RS10425 (HQ618_10370) 2059537..2059689 - 153 Protein_1985 DUF1492 domain-containing protein -
HQ618_RS10430 (HQ618_10375) 2059696..2060184 - 489 WP_000891151.1 hypothetical protein -
HQ618_RS10435 (HQ618_10380) 2060257..2060814 - 558 WP_001258765.1 hypothetical protein -
HQ618_RS10440 (HQ618_10385) 2060972..2061145 - 174 WP_000694573.1 hypothetical protein -
HQ618_RS10445 (HQ618_10390) 2061142..2061399 - 258 WP_001069293.1 hypothetical protein -
HQ618_RS10450 (HQ618_10395) 2061692..2063086 - 1395 WP_000656430.1 VapE family protein -
HQ618_RS10455 (HQ618_10400) 2063098..2063955 - 858 WP_001029296.1 primase alpha helix C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2057712..2087292 29580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 5.1643

>T158242 WP_000253103.1 NZ_CP053890:c2058839-2058492 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Download         Length: 348 bp

>T158242 NZ_CP069600:c1319880-1319344 [Dickeya dianthicola]
ATGGTAGATACTCAAAGTGAAAGTAATGGTGTAGTGGTATACGCGTATCAGGCAGATACCACATACCCTGGGAGTAAGAG
TTTCGATTGCGGAAATACCGTAATCAACTCTTTTGTGCGTAGCTCCCTCAAGAAAAGCGTCAGAGATGGGAATTGTGCAG
CTAAAGTATTGGTTAAAGATGAAACAAAAGAGCTGTTGGGTTTCTGTACTTTTGCTGCTTACTCTCTTGAAAAAAGTAAG
TTGGCGGGGGTGGTTTCAGGTTCATTGCCTCATGAATTAGGGGTTGTTCGGCTAATTATGCTGGGGGTAGCCACGAAAGA
ACAGAATAAAGGCTATGGACAAGAACTGCTTTTAGAATTCTTTAAACAGGTTAAAACCATCCACGAATCGCTACCTGTTA
AAGGCGTGTATTTGGATGCGGATCCGGCAGCAATTGACTTCTATATCCGGTTAGGTTTCGTTCAACTTAATGAACCACCG
AATGCTTTTGGTGCGGTGCCCATGTTTTTGGCCATTCAACATATCCTTGCTGCGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT158242 WP_000543070.1 NZ_CP053890:c2059116-2058829 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp

>AT158242 NZ_CP069600:c1320172-1319861 [Dickeya dianthicola]
ATGTCTAATGTATCAGTGTTTCCCAATGATATTCGCGTCACGAAGAACGCGCGGGTGGAGTTAAAAACTAGCCCTGACCT
TAAAGATGTGCTTCGTGAAGCAGCTACGGCTGCAGGTTTAGATTTGAGTGCGTTTATTCTTAATGCCGCCCTGGAGCGAG
CAGAAAGCGTCCTGGATAACCAGCGGCGCCGACAGCTTTCAGCAGCAAGCTGGCAACAATTAAACCAACTCTTGTCTGAA
CCTGCTGCACCGACGCTGGCTTTACAGGCGTTAATGCAGAGGAAGAAACAAGATGGTAGATACTCAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076ZDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References