Detailed information of TA system TA158241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 238925..239537
• Replicon: chromosome
• Accession: NZ_CP053890
• Organism: Streptococcus agalactiae strain GBS68

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: HQ618_RS01410
• Protein ID: WP_000384859.1
• Coordinates: 238925..239260 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: HQ618_RS01415
• Protein ID: WP_000259017.1
• Coordinates: 239250..239537 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQ618_RS01385 (HQ618_01380)	234123..234764	+	642	Protein_217	hypothetical protein	-
HQ618_RS01390 (HQ618_01385)	235064..235939	+	876	WP_000421240.1	hypothetical protein	-
HQ618_RS01395 (HQ618_01390)	235975..236409	+	435	WP_001220479.1	hypothetical protein	-
HQ618_RS01400 (HQ618_01395)	236726..237982	+	1257	WP_000122836.1	MobV family relaxase	-
HQ618_RS01405 (HQ618_01400)	238150..238620	+	471	WP_000130119.1	hypothetical protein	-
HQ618_RS01410 (HQ618_01405)	238925..239260	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HQ618_RS01415 (HQ618_01410)	239250..239537	-	288	WP_000259017.1	hypothetical protein	Antitoxin
HQ618_RS01420 (HQ618_01415)	239940..241160	-	1221	WP_000156558.1	site-specific integrase	-
HQ618_RS01425 (HQ618_01420)	241221..241481	-	261	WP_001196072.1	helix-turn-helix domain-containing protein	-
HQ618_RS01430 (HQ618_01425)	241493..242239	-	747	WP_000966632.1	hypothetical protein	-
HQ618_RS01435 (HQ618_01430)	242425..243216	-	792	WP_001868842.1	hypothetical protein	-
HQ618_RS01440 (HQ618_01435)	243197..243730	-	534	WP_000680721.1	hypothetical protein	-
HQ618_RS01445 (HQ618_01440)	243730..244068	-	339	WP_001187920.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	232356..245443	13087

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T158241 WP_000384859.1 NZ_CP053890:c239260-238925 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T158241 NZ_CP069600:c1259145-1258942 [Dickeya dianthicola]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAAATACGTTCGTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT158241 WP_000259017.1 NZ_CP053890:c239537-239250 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT158241 NZ_CP069600:c1259567-1259199 [Dickeya dianthicola]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGATAGCAGTCGTAGCTGGGTGAATGACCCGACTTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCTGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGTAACTACGGTATAAATGACGCCGAGTTGCAGAAATGGCGAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6