Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
| Location | 2062163..2062787 | Replicon | chromosome |
| Accession | NZ_CP053888 | ||
| Organism | Streptococcus agalactiae strain SS44 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A076ZDW1 |
| Locus tag | HQ615_RS10375 | Protein ID | WP_000253103.1 |
| Coordinates | 2062163..2062510 (-) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A076YVN5 |
| Locus tag | HQ615_RS10380 | Protein ID | WP_000543070.1 |
| Coordinates | 2062500..2062787 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HQ615_RS10355 (HQ615_10315) | 2057878..2058234 | - | 357 | WP_000105934.1 | DUF1304 domain-containing protein | - |
| HQ615_RS10360 (HQ615_10320) | 2058301..2060619 | - | 2319 | WP_235083256.1 | YhgE/Pip domain-containing protein | - |
| HQ615_RS10365 (HQ615_10325) | 2060758..2061297 | + | 540 | WP_029140677.1 | TetR/AcrR family transcriptional regulator | - |
| HQ615_RS10370 (HQ615_10330) | 2061383..2061679 | - | 297 | WP_001052249.1 | DUF4298 domain-containing protein | - |
| HQ615_RS10375 (HQ615_10335) | 2062163..2062510 | - | 348 | WP_000253103.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HQ615_RS10380 (HQ615_10340) | 2062500..2062787 | - | 288 | WP_000543070.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HQ615_RS10385 (HQ615_10345) | 2062856..2063233 | - | 378 | WP_000038826.1 | ArpU family phage packaging/lysis transcriptional regulator | - |
| HQ615_RS10390 (HQ615_10350) | 2063208..2063360 | - | 153 | Protein_1984 | DUF1492 domain-containing protein | - |
| HQ615_RS10395 (HQ615_10355) | 2063367..2063855 | - | 489 | WP_000891151.1 | hypothetical protein | - |
| HQ615_RS10400 (HQ615_10360) | 2063928..2064485 | - | 558 | WP_001258765.1 | hypothetical protein | - |
| HQ615_RS10405 (HQ615_10365) | 2064643..2064816 | - | 174 | WP_000694573.1 | hypothetical protein | - |
| HQ615_RS10410 (HQ615_10370) | 2064813..2065070 | - | 258 | WP_001069293.1 | hypothetical protein | - |
| HQ615_RS10415 (HQ615_10375) | 2065363..2066757 | - | 1395 | WP_000656430.1 | VapE family protein | - |
| HQ615_RS10420 (HQ615_10380) | 2066769..2067626 | - | 858 | WP_001029296.1 | primase alpha helix C-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2061383..2075961 | 14578 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13333.09 Da Isoelectric Point: 5.1643
>T158238 WP_000253103.1 NZ_CP053888:c2062510-2062163 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK
Download Length: 348 bp
>T158238 NZ_CP069600:733246-733677 [Dickeya dianthicola]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGCTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGTCGGACGGCTATGCGCCGCTGTGGTTGGGCCTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGTTCGGCGCCCGTGGGTAATGCGCAACGGCGTGTTGCTGTCATTGCGGGCAACGAATGGCAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGTAACGAAGAATGGCGGCTGTTGCGCCAACTGTTGCAGCAGCATCCGT
TGCAGGGAACCGAATCCTCCCGCCATCATTAA
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGCTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGTCGGACGGCTATGCGCCGCTGTGGTTGGGCCTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGTTCGGCGCCCGTGGGTAATGCGCAACGGCGTGTTGCTGTCATTGCGGGCAACGAATGGCAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGTAACGAAGAATGGCGGCTGTTGCGCCAACTGTTGCAGCAGCATCCGT
TGCAGGGAACCGAATCCTCCCGCCATCATTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10605.98 Da Isoelectric Point: 4.8430
>AT158238 WP_000543070.1 NZ_CP053888:c2062787-2062500 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI
Download Length: 288 bp
>AT158238 NZ_CP069600:732999-733265 [Dickeya dianthicola]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAATATGACACGCTGAGCGACGACGACAAGCTGCACTTCATTCGTCTGCTGCAGTGCGATGATCCCGACT
TGTTCAACTGGCTGATGAATCATGGCGAGCCGGTAGATCCGGCGCTGAAACGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAATATGACACGCTGAGCGACGACGACAAGCTGCACTTCATTCGTCTGCTGCAGTGCGATGATCCCGACT
TGTTCAACTGGCTGATGAATCATGGCGAGCCGGTAGATCCGGCGCTGAAACGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A076ZDW1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A076YVN5 |