Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 250301..250913 Replicon chromosome
Accession NZ_CP053888
Organism Streptococcus agalactiae strain SS44

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag HQ615_RS01465 Protein ID WP_000384858.1
Coordinates 250301..250636 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag HQ615_RS01470 Protein ID WP_000255538.1
Coordinates 250626..250913 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ615_RS01440 (HQ615_01440) 245488..246117 + 630 WP_000591148.1 hypothetical protein -
HQ615_RS01445 (HQ615_01445) 246441..247316 + 876 WP_000770113.1 hypothetical protein -
HQ615_RS01450 (HQ615_01450) 247352..247786 + 435 WP_001220479.1 hypothetical protein -
HQ615_RS01455 (HQ615_01455) 248102..249358 + 1257 WP_000122832.1 MobV family relaxase -
HQ615_RS01460 (HQ615_01460) 249526..249996 + 471 WP_000130119.1 hypothetical protein -
HQ615_RS01465 (HQ615_01465) 250301..250636 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ615_RS01470 (HQ615_01470) 250626..250913 - 288 WP_000255538.1 hypothetical protein Antitoxin
HQ615_RS01475 (HQ615_01475) 251316..252536 - 1221 WP_000156558.1 site-specific integrase -
HQ615_RS01480 (HQ615_01480) 252597..252857 - 261 WP_001196072.1 helix-turn-helix domain-containing protein -
HQ615_RS01485 (HQ615_01485) 252869..253615 - 747 WP_000966632.1 hypothetical protein -
HQ615_RS01490 (HQ615_01490) 253801..254592 - 792 WP_001868842.1 hypothetical protein -
HQ615_RS01495 (HQ615_01495) 254573..255106 - 534 WP_000680721.1 hypothetical protein -
HQ615_RS01500 (HQ615_01500) 255106..255444 - 339 WP_001187920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 190600..252641 62041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T158237 WP_000384858.1 NZ_CP053888:c250636-250301 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T158237 NZ_CP069600:c474341-473862 [Dickeya dianthicola]
GTGGGAATAACGGCACCTGAATTATTGCTGCCTCAACATGCGGTTGTGGATTTTCATTGTTCAGAGCCGTCATTGAATGA
ATGGCTGAAACGCAAGGCGTTAAAAAATCAGACGCTGGGCGCTTCACGCACCTTCGTGGTGTGTGAAGCCGGTACACAGC
GTGTGGTGGGGTTCTATGCCCTCGCGTCGGGCAGCATCCAGCGTCAGGTTGCGCCGGGCGCATTCCGGCGCAATATGCCT
GACCCCATTCCTGTTCTGGTGCTCGGTAGATTAGCCGTTGATGAACGTTATCAACGTATGGGGATCGGTGCCGGGCTCCT
GAAAGATGCGGTACTCCGCTCCCGCAATGTAGCGCAGCAGGTAGGCAACAAAGCGTTATTGGTACATGCGTTATCTGATG
AGGCAAAAGCGTTCTACCAATACTGGGGTTTTGTCCCGTCAGAAATACAGGAACACACCTTATTATTATCGTTATGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT158237 WP_000255538.1 NZ_CP053888:c250913-250626 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT158237 NZ_CP069600:c474604-474332 [Dickeya dianthicola]
ATGCGAACAGAGACAAAAGAAACGCCGATTAATATTCGTGCTAAAGCATCACAGCGGGAGCTGATTGATGTCGCCGCTAA
ATTGCTGTCGAAATCAAGAACAGAGTTTATCCTTGATGCTGCCTGCCGTGAGGCTGAGGATGTGTTGTTGGATCAAAGGC
TGTTTCTGGTCAATGATGAACAATATGATGCTTTCATTCAGGTGCTGGAATCACCTGTCACAGATAATCCGCGTATGAAT
GCATTACTGAACAGGAAATCTCCGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References