Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
| Location | 2043995..2044619 | Replicon | chromosome |
| Accession | NZ_CP053887 | ||
| Organism | Streptococcus agalactiae strain SS102 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A076ZDW1 |
| Locus tag | HQ611_RS10330 | Protein ID | WP_000253103.1 |
| Coordinates | 2043995..2044342 (-) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A076YVN5 |
| Locus tag | HQ611_RS10335 | Protein ID | WP_000543070.1 |
| Coordinates | 2044332..2044619 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HQ611_RS10310 (HQ611_10260) | 2039710..2040066 | - | 357 | WP_000105934.1 | DUF1304 domain-containing protein | - |
| HQ611_RS10315 (HQ611_10265) | 2040133..2042451 | - | 2319 | WP_000883414.1 | YhgE/Pip domain-containing protein | - |
| HQ611_RS10320 (HQ611_10270) | 2042590..2043129 | + | 540 | WP_000245858.1 | TetR/AcrR family transcriptional regulator C-terminal domain-containing protein | - |
| HQ611_RS10325 (HQ611_10275) | 2043215..2043511 | - | 297 | WP_001052249.1 | DUF4298 domain-containing protein | - |
| HQ611_RS10330 (HQ611_10280) | 2043995..2044342 | - | 348 | WP_000253103.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HQ611_RS10335 (HQ611_10285) | 2044332..2044619 | - | 288 | WP_000543070.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HQ611_RS10340 (HQ611_10290) | 2044688..2045065 | - | 378 | WP_000038826.1 | ArpU family phage packaging/lysis transcriptional regulator | - |
| HQ611_RS10345 (HQ611_10295) | 2045040..2045192 | - | 153 | Protein_1973 | DUF1492 domain-containing protein | - |
| HQ611_RS10350 (HQ611_10300) | 2045199..2045687 | - | 489 | WP_000891151.1 | hypothetical protein | - |
| HQ611_RS10355 (HQ611_10305) | 2045760..2046317 | - | 558 | WP_001258765.1 | hypothetical protein | - |
| HQ611_RS10360 (HQ611_10310) | 2046475..2046648 | - | 174 | WP_000694573.1 | hypothetical protein | - |
| HQ611_RS10365 (HQ611_10315) | 2046645..2046902 | - | 258 | WP_001069293.1 | hypothetical protein | - |
| HQ611_RS10370 (HQ611_10320) | 2047195..2048589 | - | 1395 | WP_000656430.1 | VapE family protein | - |
| HQ611_RS10375 (HQ611_10325) | 2048601..2049458 | - | 858 | WP_001029296.1 | primase alpha helix C-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2043215..2072795 | 29580 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13333.09 Da Isoelectric Point: 5.1643
>T158236 WP_000253103.1 NZ_CP053887:c2044342-2043995 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK
Download Length: 348 bp
>T158236 NZ_CP069599:2369371-2369841 [Dickeya dianthicola]
TTGATTCTCTACAGGCTGACCAAGACAAAATATCTTTCTACAGTCTGGACGGGATATGGGGCAAAAGAGGCAGGAGGTCG
CTGGAACAGTGTAGGTGTCTCGATGGTATATGTGTCTGAAACAGCATCGCTTACGATGCTTGAGACGCTTGTACATCTGC
ATGCTGCACATATTCTGGATTATTATACTCTGCTGCGTATTGATGTCCCTGATGACCATATTCAGAGCGTCAATATGAAC
GACTTGCCAGAAAATTGGGCTGAAGAAGACGCGCCGCCTGAGCTTGCTGCTTACGGTGATGCTTGGTGCTTTACCAAAAG
TTCGATAGCCTTGCGTGTCCCCAGCACTTTATCTCCCGTGGAATTTAACTACCTTTTAAACCCCGAGCACCCTGACTTCT
CCTCGATCATCCAGAACGCTGACACCATTCCGTTCCAGTTTGATAGCAGGCTGAAACCGGCGATTAAATAG
TTGATTCTCTACAGGCTGACCAAGACAAAATATCTTTCTACAGTCTGGACGGGATATGGGGCAAAAGAGGCAGGAGGTCG
CTGGAACAGTGTAGGTGTCTCGATGGTATATGTGTCTGAAACAGCATCGCTTACGATGCTTGAGACGCTTGTACATCTGC
ATGCTGCACATATTCTGGATTATTATACTCTGCTGCGTATTGATGTCCCTGATGACCATATTCAGAGCGTCAATATGAAC
GACTTGCCAGAAAATTGGGCTGAAGAAGACGCGCCGCCTGAGCTTGCTGCTTACGGTGATGCTTGGTGCTTTACCAAAAG
TTCGATAGCCTTGCGTGTCCCCAGCACTTTATCTCCCGTGGAATTTAACTACCTTTTAAACCCCGAGCACCCTGACTTCT
CCTCGATCATCCAGAACGCTGACACCATTCCGTTCCAGTTTGATAGCAGGCTGAAACCGGCGATTAAATAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10605.98 Da Isoelectric Point: 4.8430
>AT158236 WP_000543070.1 NZ_CP053887:c2044619-2044332 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI
Download Length: 288 bp
>AT158236 NZ_CP069599:2368931-2369374 [Dickeya dianthicola]
ATGAAAACATTTAGCTTATCCACGACACAGACCCGGCCGCCACGCTTGTGGCAGGTTGCGGGGTTAAACAATTCTGATGG
TGTAGCACTGCTGGGCCAGATTAACGAAGGCCTTGATGGCACAGTTGCAAACGTGATCATTGACTGGGCAAAGATCACGC
AGAACGACCTGCGCAAAATGTCCGGTATACCGTCCACGACATTCAGTCGTAGCCGGAAAGCCCGATTCACCGCCGACCAA
AGTGAGCGACTGGTGCGCATTATTCGCGTTATAGATCGGGCTGTAGAACTGTTCGAGGGTGATAAAGACGAGGCCCAGAA
ATGGTTGAATGAGCCAAACAGAGCACTGAGCTGGAAAGTGCCAGCGGAACTGATGGCCTCCGAAACCGGCGCTTACGAGG
TCATGAAATTGATTACACGCCTGGAGCATGGGGCATACTCTTGA
ATGAAAACATTTAGCTTATCCACGACACAGACCCGGCCGCCACGCTTGTGGCAGGTTGCGGGGTTAAACAATTCTGATGG
TGTAGCACTGCTGGGCCAGATTAACGAAGGCCTTGATGGCACAGTTGCAAACGTGATCATTGACTGGGCAAAGATCACGC
AGAACGACCTGCGCAAAATGTCCGGTATACCGTCCACGACATTCAGTCGTAGCCGGAAAGCCCGATTCACCGCCGACCAA
AGTGAGCGACTGGTGCGCATTATTCGCGTTATAGATCGGGCTGTAGAACTGTTCGAGGGTGATAAAGACGAGGCCCAGAA
ATGGTTGAATGAGCCAAACAGAGCACTGAGCTGGAAAGTGCCAGCGGAACTGATGGCCTCCGAAACCGGCGCTTACGAGG
TCATGAAATTGATTACACGCCTGGAGCATGGGGCATACTCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A076ZDW1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A076YVN5 |