Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2043995..2044619 Replicon chromosome
Accession NZ_CP053887
Organism Streptococcus agalactiae strain SS102

Toxin (Protein)


Gene name parE Uniprot ID A0A076ZDW1
Locus tag HQ611_RS10330 Protein ID WP_000253103.1
Coordinates 2043995..2044342 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag HQ611_RS10335 Protein ID WP_000543070.1
Coordinates 2044332..2044619 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ611_RS10310 (HQ611_10260) 2039710..2040066 - 357 WP_000105934.1 DUF1304 domain-containing protein -
HQ611_RS10315 (HQ611_10265) 2040133..2042451 - 2319 WP_000883414.1 YhgE/Pip domain-containing protein -
HQ611_RS10320 (HQ611_10270) 2042590..2043129 + 540 WP_000245858.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
HQ611_RS10325 (HQ611_10275) 2043215..2043511 - 297 WP_001052249.1 DUF4298 domain-containing protein -
HQ611_RS10330 (HQ611_10280) 2043995..2044342 - 348 WP_000253103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ611_RS10335 (HQ611_10285) 2044332..2044619 - 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HQ611_RS10340 (HQ611_10290) 2044688..2045065 - 378 WP_000038826.1 ArpU family phage packaging/lysis transcriptional regulator -
HQ611_RS10345 (HQ611_10295) 2045040..2045192 - 153 Protein_1973 DUF1492 domain-containing protein -
HQ611_RS10350 (HQ611_10300) 2045199..2045687 - 489 WP_000891151.1 hypothetical protein -
HQ611_RS10355 (HQ611_10305) 2045760..2046317 - 558 WP_001258765.1 hypothetical protein -
HQ611_RS10360 (HQ611_10310) 2046475..2046648 - 174 WP_000694573.1 hypothetical protein -
HQ611_RS10365 (HQ611_10315) 2046645..2046902 - 258 WP_001069293.1 hypothetical protein -
HQ611_RS10370 (HQ611_10320) 2047195..2048589 - 1395 WP_000656430.1 VapE family protein -
HQ611_RS10375 (HQ611_10325) 2048601..2049458 - 858 WP_001029296.1 primase alpha helix C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2043215..2072795 29580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 5.1643

>T158236 WP_000253103.1 NZ_CP053887:c2044342-2043995 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Download         Length: 348 bp

>T158236 NZ_CP069599:2369371-2369841 [Dickeya dianthicola]
TTGATTCTCTACAGGCTGACCAAGACAAAATATCTTTCTACAGTCTGGACGGGATATGGGGCAAAAGAGGCAGGAGGTCG
CTGGAACAGTGTAGGTGTCTCGATGGTATATGTGTCTGAAACAGCATCGCTTACGATGCTTGAGACGCTTGTACATCTGC
ATGCTGCACATATTCTGGATTATTATACTCTGCTGCGTATTGATGTCCCTGATGACCATATTCAGAGCGTCAATATGAAC
GACTTGCCAGAAAATTGGGCTGAAGAAGACGCGCCGCCTGAGCTTGCTGCTTACGGTGATGCTTGGTGCTTTACCAAAAG
TTCGATAGCCTTGCGTGTCCCCAGCACTTTATCTCCCGTGGAATTTAACTACCTTTTAAACCCCGAGCACCCTGACTTCT
CCTCGATCATCCAGAACGCTGACACCATTCCGTTCCAGTTTGATAGCAGGCTGAAACCGGCGATTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT158236 WP_000543070.1 NZ_CP053887:c2044619-2044332 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp

>AT158236 NZ_CP069599:2368931-2369374 [Dickeya dianthicola]
ATGAAAACATTTAGCTTATCCACGACACAGACCCGGCCGCCACGCTTGTGGCAGGTTGCGGGGTTAAACAATTCTGATGG
TGTAGCACTGCTGGGCCAGATTAACGAAGGCCTTGATGGCACAGTTGCAAACGTGATCATTGACTGGGCAAAGATCACGC
AGAACGACCTGCGCAAAATGTCCGGTATACCGTCCACGACATTCAGTCGTAGCCGGAAAGCCCGATTCACCGCCGACCAA
AGTGAGCGACTGGTGCGCATTATTCGCGTTATAGATCGGGCTGTAGAACTGTTCGAGGGTGATAAAGACGAGGCCCAGAA
ATGGTTGAATGAGCCAAACAGAGCACTGAGCTGGAAAGTGCCAGCGGAACTGATGGCCTCCGAAACCGGCGCTTACGAGG
TCATGAAATTGATTACACGCCTGGAGCATGGGGCATACTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076ZDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References