Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2775869..2777457 | Replicon | chromosome |
| Accession | NZ_CP053875 | ||
| Organism | Klebsiella pneumoniae strain KPN142 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A0H3GN97 |
| Locus tag | HPY03_RS13830 | Protein ID | WP_004199851.1 |
| Coordinates | 2775869..2777191 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | HPY03_RS13835 | Protein ID | WP_002904790.1 |
| Coordinates | 2777191..2777457 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY03_RS13815 (HPY03_13795) | 2770934..2773435 | + | 2502 | WP_004199853.1 | fimbria/pilus outer membrane usher protein | - |
| HPY03_RS13820 (HPY03_13800) | 2773423..2774427 | + | 1005 | WP_004199852.1 | fimbrial protein | - |
| HPY03_RS13825 (HPY03_13805) | 2774560..2775852 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| HPY03_RS13830 (HPY03_13810) | 2775869..2777191 | - | 1323 | WP_004199851.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HPY03_RS13835 (HPY03_13815) | 2777191..2777457 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| HPY03_RS13840 (HPY03_13820) | 2777723..2778049 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| HPY03_RS13845 (HPY03_13825) | 2778046..2778546 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| HPY03_RS13850 (HPY03_13830) | 2778524..2779903 | - | 1380 | WP_004199850.1 | nucleobase:cation symporter-2 family protein | - |
| HPY03_RS13855 (HPY03_13835) | 2780249..2781403 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| HPY03_RS13860 (HPY03_13840) | 2781384..2782307 | - | 924 | WP_004199849.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.2487
>T158221 WP_004199851.1 NZ_CP053875:c2777191-2775869 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T158221 NZ_CP069598:1578334-1578648 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGCCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGGCGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG
ATGCAATTCACCGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGCCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGGCGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT158221 WP_002904790.1 NZ_CP053875:c2777457-2777191 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT158221 NZ_CP069598:1578095-1578331 [Dickeya dianthicola]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGCTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACCGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGCTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACCGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GN97 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |