158212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874643..875297 Replicon chromosome
Accession NZ_CP053875
Organism Klebsiella pneumoniae strain KPN142

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag HPY03_RS04425 Protein ID WP_004144731.1
Coordinates 874890..875297 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HPY03_RS04420 Protein ID WP_002916312.1
Coordinates 874643..874909 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY03_RS04395 (HPY03_04390) 869799..871232 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HPY03_RS04400 (HPY03_04395) 871351..872079 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HPY03_RS04405 (HPY03_04400) 872129..872440 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HPY03_RS04410 (HPY03_04405) 872604..873263 + 660 WP_002916317.1 hemolysin III family protein -
HPY03_RS04415 (HPY03_04410) 873414..874397 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HPY03_RS04420 (HPY03_04415) 874643..874909 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HPY03_RS04425 (HPY03_04420) 874890..875297 + 408 WP_004144731.1 protein YgfX Toxin
HPY03_RS04430 (HPY03_04425) 875304..875825 - 522 WP_002916308.1 flavodoxin FldB -
HPY03_RS04435 (HPY03_04430) 875926..876822 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HPY03_RS04440 (HPY03_04435) 876845..877558 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HPY03_RS04445 (HPY03_04440) 877564..879297 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T158212 WP_004144731.1 NZ_CP053875:874890-875297 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T158212 NZ_CP069597:1862994-1863308 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT158212 WP_002916312.1 NZ_CP053875:874643-874909 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT158212 NZ_CP069597:1862755-1862991 [Dickeya dianthicola]
ATGACCGCGAAACAGCGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGGTCCGGGCGCGTGAGGCGGG
CATTAACCTGAGTGCCACTCTGACAACCGCCCTGGATGCCGAGCTTCGCCGTCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGTTTTCATGATGAGCACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References