Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 327831..328417 | Replicon | chromosome |
| Accession | NZ_CP053875 | ||
| Organism | Klebsiella pneumoniae strain KPN142 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | W8VD46 |
| Locus tag | HPY03_RS01525 | Protein ID | WP_002920800.1 |
| Coordinates | 328049..328417 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A0H3GZM4 |
| Locus tag | HPY03_RS01520 | Protein ID | WP_002920802.1 |
| Coordinates | 327831..328052 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY03_RS01500 (HPY03_01500) | 323988..324914 | + | 927 | WP_002920807.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| HPY03_RS01505 (HPY03_01505) | 324911..326188 | + | 1278 | WP_002920806.1 | branched chain amino acid ABC transporter permease LivM | - |
| HPY03_RS01510 (HPY03_01510) | 326185..326952 | + | 768 | WP_002920803.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| HPY03_RS01515 (HPY03_01515) | 326954..327667 | + | 714 | WP_004145133.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| HPY03_RS01520 (HPY03_01520) | 327831..328052 | + | 222 | WP_002920802.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY03_RS01525 (HPY03_01525) | 328049..328417 | + | 369 | WP_002920800.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| HPY03_RS01530 (HPY03_01530) | 328690..330006 | + | 1317 | WP_002920796.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| HPY03_RS01535 (HPY03_01535) | 330113..331000 | + | 888 | WP_002920792.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| HPY03_RS01540 (HPY03_01540) | 330997..331842 | + | 846 | WP_002920789.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| HPY03_RS01545 (HPY03_01545) | 331844..332914 | + | 1071 | WP_002920787.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 322817..333651 | 10834 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13552.92 Da Isoelectric Point: 8.6410
>T158209 WP_002920800.1 NZ_CP053875:328049-328417 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
Download Length: 369 bp
>T158209 NZ_CP069597:c1319880-1319344 [Dickeya dianthicola]
ATGGTAGATACTCAAAGTGAAAGTAATGGTGTAGTGGTATACGCGTATCAGGCAGATACCACATACCCTGGGAGTAAGAG
TTTCGATTGCGGAAATACCGTAATCAACTCTTTTGTGCGTAGCTCCCTCAAGAAAAGCGTCAGAGATGGGAATTGTGCAG
CTAAAGTATTGGTTAAAGATGAAACAAAAGAGCTGTTGGGTTTCTGTACTTTTGCTGCTTACTCTCTTGAAAAAAGTAAG
TTGGCGGGGGTGGTTTCAGGTTCATTGCCTCATGAATTAGGGGTTGTTCGGCTAATTATGCTGGGGGTAGCCACGAAAGA
ACAGAATAAAGGCTATGGACAAGAACTGCTTTTAGAATTCTTTAAACAGGTTAAAACCATCCACGAATCGCTACCTGTTA
AAGGCGTGTATTTGGATGCGGATCCGGCAGCAATTGACTTCTATATCCGGTTAGGTTTCGTTCAACTTAATGAACCACCG
AATGCTTTTGGTGCGGTGCCCATGTTTTTGGCCATTCAACATATCCTTGCTGCGTAG
ATGGTAGATACTCAAAGTGAAAGTAATGGTGTAGTGGTATACGCGTATCAGGCAGATACCACATACCCTGGGAGTAAGAG
TTTCGATTGCGGAAATACCGTAATCAACTCTTTTGTGCGTAGCTCCCTCAAGAAAAGCGTCAGAGATGGGAATTGTGCAG
CTAAAGTATTGGTTAAAGATGAAACAAAAGAGCTGTTGGGTTTCTGTACTTTTGCTGCTTACTCTCTTGAAAAAAGTAAG
TTGGCGGGGGTGGTTTCAGGTTCATTGCCTCATGAATTAGGGGTTGTTCGGCTAATTATGCTGGGGGTAGCCACGAAAGA
ACAGAATAAAGGCTATGGACAAGAACTGCTTTTAGAATTCTTTAAACAGGTTAAAACCATCCACGAATCGCTACCTGTTA
AAGGCGTGTATTTGGATGCGGATCCGGCAGCAATTGACTTCTATATCCGGTTAGGTTTCGTTCAACTTAATGAACCACCG
AATGCTTTTGGTGCGGTGCCCATGTTTTTGGCCATTCAACATATCCTTGCTGCGTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8181.18 Da Isoelectric Point: 4.7769
>AT158209 WP_002920802.1 NZ_CP053875:327831-328052 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK
Download Length: 222 bp
>AT158209 NZ_CP069597:c1320172-1319861 [Dickeya dianthicola]
ATGTCTAATGTATCAGTGTTTCCCAATGATATTCGCGTCACGAAGAACGCGCGGGTGGAGTTAAAAACTAGCCCTGACCT
TAAAGATGTGCTTCGTGAAGCAGCTACGGCTGCAGGTTTAGATTTGAGTGCGTTTATTCTTAATGCCGCCCTGGAGCGAG
CAGAAAGCGTCCTGGATAACCAGCGGCGCCGACAGCTTTCAGCAGCAAGCTGGCAACAATTAAACCAACTCTTGTCTGAA
CCTGCTGCACCGACGCTGGCTTTACAGGCGTTAATGCAGAGGAAGAAACAAGATGGTAGATACTCAAAGTGA
ATGTCTAATGTATCAGTGTTTCCCAATGATATTCGCGTCACGAAGAACGCGCGGGTGGAGTTAAAAACTAGCCCTGACCT
TAAAGATGTGCTTCGTGAAGCAGCTACGGCTGCAGGTTTAGATTTGAGTGCGTTTATTCTTAATGCCGCCCTGGAGCGAG
CAGAAAGCGTCCTGGATAACCAGCGGCGCCGACAGCTTTCAGCAGCAAGCTGGCAACAATTAAACCAACTCTTGTCTGAA
CCTGCTGCACCGACGCTGGCTTTACAGGCGTTAATGCAGAGGAAGAAACAAGATGGTAGATACTCAAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GUD1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GZM4 |